Publications of Biomedical Signal Interpretation & Computational Simulation (BSICoS)* Group.

These publications are included here just to facilitate downloads to those people asking for personal use copies. Some of this material is published at copyrighted journals or conference proceedings, so personal use of the download is required. In particular publications from IEEE should be downloaded according to the following IEEE note:

© 2012 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.

* Former, before 2014, Communications Technology Group (GTC): Biomedical signal applications

Journals & Books

Journals & BooksYear
J. Bolea, R. Bailón and E. Pueyo "On the standardization of approximate entropy: Multidimensional approximate entropy index evaluated on short- term HRV time series". Complexity, Article ID 4953273; pp. 1-15, 2018
Monasterio V, Castro-Mur J, Carro J "DENIS: Solving cardiac electrophysiological simulations with volunteer computing". PLOS ONE 13(10): e0205568, pp. 1-12; 2018
J. Carro, E. Pueyo, J. F. Rodríguez. "A response surface optimization approach to adjust ionic current conductances of cardiac electrophysiological models. Application to the study of potassium level changes". PLOS One. pp. 1-23; doi:10.1371/journal.pone.0204411 2018
E. Grandi, S. Morotti, E. Pueyo, B. Rodriguez "Editorial: Safety Pharmacology – Risk Assessment QT Interval Prolongation and Beyond". Frontieres in Physiology, Vol. 9, Article 678, pp. 1-5 doi: 10.3389/fphys.2018.00678 2018
D. Hernando, S. Roca, J. Sancho, Á. Alesanco, R. Bailón "Validation of the AppleWatch for heart rate variability measurements during relax and mental stress in healthy subjects". Sensors, vol. 18, n. 2619, pp. 1-11, doi: 10.3390/s18082619 2018
A. Rapalis, A. Petrénas, M. Šimaityté1, R. Bailón, V. Marozas "Towards pulse rate parametrization during freeliving activities using smart wristband". Physiol. Meas. vol. 39 055007 (12pp). doi: 10.1088/1361-6579/aac24a 2018
A. Hernández-Vicente, A. Santos-Lozano, R. Bailón, C. Mayolas-Pi, P. J. Marín, N. Garatachea "Effects of the type of exercise performed on the vibration delivered during whole-body vibration exercises". Journal of Vibroengineering, Volume 20, Issue 3 pp. 1522- 1529. doi: 10.21595/jve.2018.19622 2018
A. Lyon, R. Ariga, A. Minchole, M. Mahmod, E. Ormondroyd, P. Laguna, N. de Freitas, S. Neubauer, H. Watkins, B. Rodriguez "Distinct ECG phenotypes identified in hypertrophic cardiomyopathy using machine learning associate with arrhythmic risk markers". Frontiers in Physiology; vol. 1, ar. 213, pp, 1-13, doi: 10.3389/fphys.2018.00213 2018
A. Martín-Yebra, V. Monasterio, I. Cygankiewicz, A. Bayés de Luna, E. G. Caiani, P. Laguna and J. P. Martínez "Post-ventricular premature contraction phase correction improves the predictive value of average T-wave alternans in ambulatory ECG recordings". IEEE Transactions Biomedical Engineering. vol. 65, n. 3, pp. 635--644 doi: 10.1109/TBME.2017.2711645 2018
P. Laguna; A. Garde, B. F Giraldo, O. Meste, R. Jané, L. Sörnmo, "Eigenvalue-Based Time Delay Estimation of Repetitive Biomedical Signals". Digital Signal Processing, vol. 75, pp. 107–119 doi: 10.1016/j.dsp.2018.01.007 2018
A Lyon, A Mincholé, J. P. Martínez, P. Laguna, B. Rodriguez "Computational techniques for ECG analysis and interpretation in light of their contribution to medical advances". Journal of the Royal Society: Interface.vol. 15, doi: 10.1098/rsif.2017.0821 2018
M. Holmer; J. P. Martínez; E. Gil; F. Sandberg; B. Olde; L. Sörnmo "Detection of Ventricular Premature Beats Based on the Pressure Signals of a Hemodialysis Machine". Medical Engineering & Physics. v.51, pp.49–55 doi: 10.1016/j.medengphy.2017.11.004 2018
A. Olivan-Viguera, A.L. Garcia-Otin, J. Lozano-Gerona, E. Abarca-Lachen, A.J. Garcia-Malinis, K.L Hamilton, Y. Gilaberte , E. Pueyo, R. Kohler "Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes". PlosOne vol. 13, n. 1, e0190307, pp. 1--19, doi: 10.1371/journal.pone.0190307 2018
J. Milagro, E. Gil, J. Lázaro, V.-P. Seppä, L. P. Malmberg, A. S. Pelkonen, A. Kotaniemi-Syrjänen, M. J. Mäkelä, J. Viik and R. Bailón "Nocturnal Heart Rate Variability Spectrum Characterization in Preschool Children with Asthmatic Symptoms". IEEE Journal of biomedical and health informatics, vol. 22, n. 5, pp. 1332-1340, doi: 10.1109/JBHI.2017.2775059 2018
M. Orini, E. Pueyo, P. Laguna, R. Bailón "A Time-Varying Non-Parametric Methodology for Assessing Changes in QT Variability Unrelated to Heart Rate Variability". IEEE Transactions Biomedical Engineering. v. 65, n. 7, pp. 1443- 1451 doi: 10.1109/TBME.2017.2758925 2018
M. Nardelli, A.Greco, J.Bolea, G. Valenza, E.P. Scilingo, R.Bailón "Reliability of Lagged Poincaré Plot parameters in ultra-short Heart Rate Variability series: Application on Affective Sounds". IEEE Journal of Biomedical and Health Informatics. vol. 22, n. 3, pp. 741-749, doi: 10.1109/JBHI.2017.2694999 2018
A. Alcaine, D. Soto-Iglesias, J. Acosta, V. Korshunov,D. Penela, M. Martínez, M. Linhart, D. Andreu, J. Fernández-Armenta, P. Laguna, J. P. Martínez, O. Camara, A. Berruezo "Automatic Activation Mapping and Origin Identification of Idiopathic Outflow Tract Ventricular Arrhythmias". Journal of Electrocardiology. vol. 51 pp. 239--246, doi: 10.1016/j.jelectrocard.2017.10.015 2018
D. Hernando, A. Hernando, J. A. Casajús, P. Laguna, N. Garatachea, R. Bailón "Methodological Framework for Heart Rate Variability Analysis During Exercise: Application to Running and Cycling Stress Testing". Medical & Biological Engineering & Computing, vol. 56, pp. 781-794, doi:10.1007/s11517-017-1724-9 2018
C. Sanchez, G. D’Ambrosio. F. Maffessanti, E. G. Caiani, F. W. Prinzen, R. Krause, A. Auricchio, M. Potse "Sensitivity analysis of ventricular activation and electrocardiogram in tailored models of heart-failure patients". Med Biol Eng Comput, vol. 56, pp. 491--504, doi:10.1007/s11517-017-1696-9 2018
D. Hernando, N. Garatachea, R. Almeida, J. A. Casajús, R. Bailón "Validation of heart rate monitor Polar RS800 for heart rate variability analysis during exercise". Journal of Strength and Conditioning Research, vol.32, n.3 pp. 716–725, doi: 10.1519/JSC.0000000000001662 2018
L. Sörnmo, A. Petrenas, P. Laguna, V. Marozas "BookChapter: Extraction of f waves. in Atrial Fibrillation from an Engineering Perspective". Springer. pp. 137-220, DOI: 10.1007/978-3-319-68515-1_5 2018
L. Sörnmo, R. Alcaraz, P. Laguna, J. Rieta "BookChapter: Characterization of f waves. in Atrial Fibrillation from an Engineering Perspective". Springer. pp. 221-280, DOI: 10.1007/978-3-319-68515-1_6 2018
C. Sánchez, A. Bueno-Orovio, E. Pueyo, B. Rodríguez B. "Atrial Fibrillation Dynamics and Ionic Block Effects in Six Heterogeneous Human 3D Virtual Atria with Distinct Repolarization Dynamics" Front Bioeng Biotechnol. 8;5:29. doi: 10.3389/fbioe.2017.00029.2017
W. Naujock, M. Fumagalli, L. Vandoorne, T. Baatsen, P. Boon, L. Ordovás, A. Patel, A. M. Welters, T. Vanwelden, et al. "HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients". Nat. Commun. 8, 861. DOI: 10.1038/s41467-017-00911-y 2017
J. Ramírez, M. Orini, A. Mincholé, V. Monasterio, I. Cygankiewicz, A. Bayés de Luna; J. P. Martínez, P. Laguna, E. Pueyo "Sudden cardiac death and pump failure death prediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model" PLOS ONE, 12 (10): e0186152 pp. 1-15 doi:10.1371/journal.pone.0186152 2017
J. P. Martinez, P. Laguna "Editorial: Measuring of ventricular repolarization dynamics from ambulatory ECG as non-invasive cardiac risk indices" Revista Clínica Española. 217(8): pp. 460--461, doi:10.1016/j.rce.2017.09.001 2017
M. Turon, S. Fernandez-Gonzalo, M. Jodar, G. Goma, J. Montanya, D. Hernando, R. Bailon, C. de Haro, V. Gomez-Simon, J. Lopez-Aguilar, R. Magrans, M. Martinez-Perez, J. C. Oliva, L. Blanch, "Feasibility and safety of virtual-reality-based early neurocognitive stimulation in critically ill patients". Annals of Intensive Care. vol.7, n.81 pp: 1-11, doi:10.1186/s13613-017-0303-4 2017
J. Bolea, J. Lázaro, E. Gil, E. Rovira, J. M. Remartínez, P. Laguna, E. Pueyo, A. Navarro, R. Bailón, "Pulse rate and transit time analysis to predict hypotension events after spinal anesthesia during programmed cesarean labor". Annals Biomedical Enginnering, vol. 45, n. 9, pp. 2253–2263 DOI: 10.1007/s10439-017-1864-y 2017
A. Martín-Yebra, F. Landreani, C. Casellato, E. Pavan, P.-F. Migeotte, C. Frigo, J.P. Martínez, E.G. Caiani "Evaluation of respiratory- and postural-induced changes on the ballistocardiogram signal by time warping averaging". Physiological Measurements vol 38, pp: 1426–1440 2017
J. Ramirez, M. Orini, A. Mincholé, V. Monasterio, I. Cygankiewicz; A. Bayés de Luna, J. P. Martínez, E. Pueyo, P. Laguna, "T-wave Morphology Restitution Predicts Sudden Cardiac Death in Patients with Chronic Heart Failure". Journal of the American Heart Association. 6:e005310; doi: 10.1161/JAHA.116.005310. p:1-12. 2017
D.G. Strauss, J. Vicente, L. Johannesen, K. Blinova, J. W. Mason, P. Weeke, E.R. Behr, D. Roden, R. Woosley, G. Kosova, M.A. Rosenberg, C. Newton-Cheh, "A Common Genetic Variant Risk Score is Associated with Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study". Circulation AHA; 135:1300–1310. DOI: 10.1161/CIRCULATIONAHA.116.023980 2017
J. Carro, J. F. Rodríguez-Matas, V. Monasterio, E. Pueyo "Limitations in electrophysiological model development and validation caused by differences between simulations and experimental protocols". Progress in Biophysics and Molecular Biology. vol. 129, pp. 53-64, doi: 10.1016/j.pbiomolbio.2016.11.006 2017
M. Orini, P. Laguna , L.T. Mainardi, and R. Bailón "BookChapter: Time-frequency analysis of cardiovascular signals and their dynamic interactions. in Complexity in Cardiovascular Signals". Springer. doi: 10.1007/978-3-319-58709-7_9 2017
J. Ramírez, M. Orini, J. D. Tucker, E. Pueyo and P. Laguna "Variability of ventricular repolarization dispersion quantified by time-warping the morphology of the T-waves". IEEE Transactions Biomedical Engineering. Vol. 64, n. 7, pp. 1619--1630: doi: 10.1109/TBME.2016.2614899 2017
A. Alcaine, M. Masè, A. Cristoforetti, F. Ravelli, G. Nollo, P. Laguna, J. P. Martínez, L. Faes "A Multi-Variate Predictability Framework to Assess Invasive Cardiac Activity and Interactions during Atrial Fibrillation". IEEE Transactions Biomedical Engineering. vol. 64, n. 5, pp. 1157-1168. doi:10.1109/TBME.2016.2592953. 2017
K. Blinova, J. Stohlman, J. Vicente, D. Chan, L. Johannesen, M. P. Hortigon-Vinagre, V. Zamora, G. Smith, W. J. Crumb, L. Pang, B. Lyn-Cook, J. Ross, M. Brock, S. Chvatal, D. Millard, L. Galeotti, N. Stockbridge, D. G. Strauss "Comprehensive Translational Assessment of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced ArrhythmiasToxicol". Toxicological Sciences, vol. 155 , n. 1, pp. 234-247. doi:10.1093/toxsci/kfw200 2017
A. Garde, L. Sörnmo, P. Laguna, R. Jané, S. Benito, A. Bayes-Genis, B. Giraldo "Assessment of Respiratory Flow Cycle Morphology in Patients with Chronic Heart Failure". Medical & Biological Enginering & Computing, Med Biol Eng Comput vol. 55: pp. 245–255. DOI 10.1007/s11517-016-1498-5 2017
O. Barquero-Pérez, C. Figuera, R. Goya-Esteban, I. Mora-Jiménez, F. J. Gimeno-Blanes, P. Laguna, J. P. Martínez, E. Gil, L. Sörnmo, A. García-Alberola, J. L. Rojo-Álvarez, "On the Influence of Heart Rate and Coupling Interval Prematurity on Heart Rate Turbulence". IEEE Transactions Biomedical Engineering. vol. 64, n.. 2, pp. 302-309. doi: 10.1109/TBME.2016.2554614 2017
E. Grigonyte, E. Gil, P. Laguna, L. Sornmo "Relative Peripheral Blood Volume Changes Induced by Premature Ectopic Beats and Their Role in Hemodialysis (Technical Note)". Biomedical Signal Processing and Control. vol. 31 pp. 524–528, 2017
G. Lenis, M. Kircher, J. Lázaro, R. Bailón, E. Gil,O Doessel "Separating the effect of respiration on the heart rate variability using Granger’s causality and linear filtering". Biomedical Signal Processing and Control. vol. 31 pp. 272–287, 2017
J. Vicente, P. Laguna, A. Bartra and R. Bailón. "Drowsiness Detection using Heart Rate Variability" Medical & Biological Enginering & Computing, Accepted DOI 10.1007/s11517-015-1448-7
P. Laguna, J.P. Martínez and E. Pueyo. "Techniques for ventricular repolarization instability assessment from the ECG" Proceedings of the IEEE. Vol. 104, n. 2; pp. 392-415. doi: 10.1109/JPROC.2015.25005012016
M. Baumert, A. Porta, M. A. Vos, M. Malik, J.P. Couderc, P. Laguna, G. Piccirillo, G. L. Smith, L. G. Tereshchenko, P.G.A. Volders. "QT interval variability in body surface ECG: Measurement, physiological basis, and clinical value Position statement and consensus guidance" Endorsed by the European Heart Rhythm Association jointly with the ESCWorking Group on Cardiac Cellular Electrophysiology, EP-Europace, doi:10.1093/europace/euv4052016
N. Ortigosa, M. Rodriguez-Lopez, R. Bailón , S. I. Sarvarie, M. Sitges, E. Gratacos, B. Bijnens, F. Crispi and P. Laguna. "Heart morphology differences induced by intrauterine growth restriction and preterm birth measured on the ECG at preadolescent age" J Electrocardiol, DOI: 10.1016/j.jelectrocard.2016.03.0112016
M. M. Demidova, A. Martín-Yebra, S. Koul, E. H, J. P. Martínez, D. Erlinge and P. G. Platonov. "QRS broadening due to terminal distortion is associated with the size of myocardial injury in experimental myocardial infarction" J Electrocardiol, DOI: 10.1016/j.jelectrocard.2016.03.014 vol. 49, n. 3. pp: 300-3062016
A. Alcaine, N. M. de Groot, P. Laguna, J. P. Martínez and R. P. Houben. "Spatiotemporal Model-Based Estimation of High-Density Atrial Fibrillation Activation Map" Digital Signal Proceesing, vol. 54, pp. 64--74, doi: 10.1016/j.dsp.2016.04.0022016
A. Hernando, J. Lázaro, E. Gil, A. Arza, J. M. Garzón, R. López-Antón, C. de la Cámara, P. Laguna, J. Aguiló, R. Bailón. "Inclusion of respiratory frequency information in heart rate variability analysis for stress assessment" IEEE Journal of Biomedical and Health Informatics. Vol. 20, n. 4, pp. 1016-1025 doi: 10.1109/JBHI.2016.25535782016
D.Romero; J. P. Martinez, P.Laguna, E. Pueyo. "Ischemia detection from morphological QRS angles changes" Physiological Measurement. Vol. 37, pp. 1004--1023 doi: 10.1088/0967-3334/37/7/1004
E. Pueyo M. Orini, J. F. Rodríguez, P. Taggart. "Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans" Journal of Molecular and Cellular Cardiology vol. 97, pp. 93?105. doi: 10.1016/j.yjmcc.2016.05.003

E. Pueyo, C. E. Dangerfield. J. Britton. Virág, K. Kistamás, N. Szentandrássy6, N. Jost, A. Varró, P. P. Nánási, K. Burrage, B. Rodríguez "Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition" PLOSONE pp. 1-20 doi: 10.1371/journal.pone.01514612016
Daluwatte, L. Johannesen, L Galeotti, J Vicente, D G Strauss and C G Scully. "Assessing ECG signal quality indices to discriminate ECGs with artefacts from pathologically different arrhythmic ECGs" Physiolocal Measurements. vol. 37, pp.1370?1382.2016
E. G. Caiani, A. Martin-Yebra, F. Landreani, J. Bolea, P. Laguna, P. Vaïda. "Weightlessness and cardiac rhythm disorders: current knowledge from space flight and bed-rest studies" Frontiers in Astronomy and Space Sciences, vol. 3. Arcicle 27, pp.1-6. doi: 10.3389/fspas.2016.000272016
L. Johannesen1, J. Vicente, M. Hosseini, D. G. Strauss. "Automated Algorithm for J-Tpeak and Tpeak-Tend Assessment of Drug-Induced Proarrhythmia Risk" PLOSONE. pp. 1-18, DOI:10.1371/journal.pone.0166925

J. Vicente, L. Johannesen, M. Hosseini, J. W. Mason, ,P. T. Sager, E. Pueyo, D. G. Strauss. "Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block. Detection of Late Sodium Current Block on the ECG" PLOSONE. pp. 1-16, DOI:10.1371/journal.pone.01636192016
J. Bolea, E.Pueyo, M. Orini and R. Bailón R. " Influence of heart rate in nonlinear HRV indices as a sampling rate effect evaluated on supine and standing" Front. Physiol. 7:501. p.1-12; doi:10.3389/fphys.2016.005012016
J. Vicente, L. Johannesen, J. W. Mason, W.J. Crumb, E. Pueyo, N. Stockbridge, D. G. Strauss. "Comprehensive T wave Morphology Assessment in a Randomized Clinical Study of Dofetilide, Quinidine, Ranolazine, and Verapamil" J Am Heart Assoc. 4: e001615 p:1-13, doi: 10.1161/JAHA.114.001615.2015
J. Ramírez, V. Monasterio, A. Mincholé, M. Llamedo, G. Lenis, I. Cygankiewicz, A. Bayés de Luna, M. Malik, J. P. Martínez, P. Laguna, E. Pueyo. "Automatic SVM classification of Sudden Cardiac Death and Pump Failure Death from Autonomic and Repolarization ECG Markers" Journal of Electrocardiology, vol. 48, pp. 551-557, doi: 10.1016/j.jelectrocard.2015.04.0022015
P. MacFarlane, P. Laguna, G. Krastacic. "Computing in Cardiology (CinC) A report from the 41st Annual CinC meeting in Cambridge, MA, USA, head on 7-10 September 2014" Cardiopulse,
doi:10.1093/eurheartj/ehu483, pp. 331.
A. Mincholé, A. Bueno-Orovio, P. Laguna , E. Pueyo, and B. Rodriguez. "ECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk" Journal of Electrocardiology, vol. 48 pp. 867-873. doi: 10.1016/j.jelectrocard.2015.06.0062015
A. Martin-Yebra, E.G. Caiani, V. Monasterio, A. Pellegrini, P. Laguna, J.P. Martinez. "Evaluation of T-wave alternans activity under stress conditions after 5 days and 21 days of sedentary head-down bed-rest" Physiological measurement, vol 36, pp. 2041. 2055, doi:10.1088/0967-3334/36/10/20412015
Galeotti, L. and Scully, C.G. and Vicente, J. and Johannesen, L. and Strauss, D.G. "Robust algorithm to locate heart beats from multiple physiological waveforms by individual signal detector voting" Physiol Meas. 2015 Aug;36(8):1705-16. doi: 10.1088/0967-3334/36/8/1705.2015
J. Vicente and L. Johannesen and J.W. Mason and E. Pueyo and N. Stockbridge and D. G. Strauss. "Sex Differences in Drug-Induced Changes in Ventricular Repolarization" J Electrocardiol, 48 (2015) 1081 . 1087 doi: 10.1016/j.jelectrocard.2015.08.0042015
M. Lorenzo-Tejedor, C. De la Cámara, R. Lopez-Anton, R. Bailón, J. Aguiló, ML. Bernal Ruiz. "Direct Infussion Electrospray Mass Spectrometry as a new non-invasive tool for Serum Metabolomics in Induced-Stress Subject" European Journal of Psychiatry. Vol. 29, N.° 4, pp. 259-275
D. Hernando, L. Sörnmo, F. Sandberg, P. Laguna, M. Llamedo, R. Bailón. "Identification of Hypotension Prone Patients During Hemodialysis based on the Analysis of Heart Rate Variability" Medical & Enginering & Physics, Vol. 37, n.12 , pp. 1156-1161 doi:10.1016/j.medengphy.2015.10.003.2015
J. Aguiló, P. Ferrer-Salvans, A. García-Rozo, A.Armario, A. Corbí, F.J. Cambra, R. Bailón, A. González-Marcos, G. Caja, S. Aguiló, R. López-Antón, A. Arza-Valdés, J. M. Garzón-Rey. "Project ES3: attempting to quantify and measure the level of stress" Rev Neurol; 61: 405-152015
J. Lázaro, Y. Nam, E. Gil, P. Laguna, K. Chon. "Respiratory rate derived from smartphone-cameraacquired pulse photoplethysmographic signals" Physiological Measurement, vol. 36, pp. 2317-2333 doi:10.1088/0967-3334/36/11/2317.2015
L. Galeotti, P. M. van Dam, L. Johannesen, J. Vicente, D. G. Strauss. "Computer simulations to investigate the causes of T-wave notching" Journal of Electrocardiology vol. 48, pp. 927 . 932.2015
J.M. Gorriz, J Ramirez, A. Olivares, P. Padilla, C.G. Puntoner, M. Cantón and P. Laguna. "Real Time QRS Detection based on M-ary Likelihood Ratio Test on the DFT coefficients" PLOS ONE, Vol. 9, n. 10, e110629, doi:10.1371/journal.pone.0110629.2014
J. Ramírez, P. Laguna, A. Bayés de Luna, M. Malik, E. Pueyo. "QT/RR and T-peak-to-end/RR curvatures and slopes in chronic heart failure: Relation to sudden cardiac death" Journal of Electrocardiology, vol. 47 pp. 842. 848 doi: 10.1016/j.jelectrocard.2014.08.013.2014
O. Sayadi, D. Puppala, N. Ishaque, R. Doddamani, F. M Merchant, C. Barrett, J. P Singh, E. K. Heist, T. Mela, J. P. Martínez, P. Laguna, A. A Armoundas. "A Novel Method to Capture the Onset of Dynamic Electrocardiographic Ischemic Changes and its Implications to Arrhythmia Susceptibility" Journal of the American Heart Association (JAHA). e001055; pp. 1-13 doi: 10.1161/JAHA.114.001055 3:2014
J. Lázaro, A. Alcaine, D. Romero, E. Gil, P. Laguna, E. Pueyo, and R. Bailón. "Electrocardiogram Derived Respiratory Rate from QRS Slopes and R-wave Angle" Annals Biomedical Enginnering, Vol. 40, No. 10, October 2014, pp. 2072.2083 DOI: 10.1007/s10439-014-1073-x.2014
A. Mincholé, L. Sörnmo, and P. Laguna. "Detection of Body Position Changes from the ECG using a Laplacian Noise Model" Biomedical Signal Processing and Control, vol. 14 pp. 189--196 doi: 10.1016/j.bspc.2014.08.002.2014
C. Sánchez, A. Bueno-Orovio, E. Wettwer, S. Loose, U. Ravens, E. Pueyo, B. Rodríguez. "Inter-subject variability in human atrial action potential in sinus rhythm versus chronic atrial fibrillation" PLOS ONE, Vol. 9, n.8, e105897, doi:10.1371/journal.pone.0105897.2014
F. Sandberg, R. Bailón, D. Hernando, P. Laguna, J.P. Martínez, K. Solem, L. Sörnmo. "Prediction of hypotension in hemodialysis patients" Physiological Measurement. vol. 35, pp. 1885--1898; doi:10.1088/0967-3334/35/9/1885.2014
A. Mincholé, E Zacur, E. Pueyo, P. Laguna. "Modeling and Quantification of Repolarization Feature Dependency on Heart Rate" Selected paper for the Special 2013 issue of methods of information in medicine, vol. 53, n. 4, pp. 324-8. doi: 10.3414/ME13-02-0040.2014
A. Alcaine, D. Soto-Iglesias, M. Calvo, E. Guiu, D. Andreu, J. Fernández-Armenta, A. Berruezo, P. Laguna, O. Camara and J. P. Martínez. "A Wavelet-Based Electrogram Onset Delineator for Automatic Ventricular Activation Mapping" IEEE Trans. on Biomedical Engineering. v. 61, n. 12, pp. 2830-2839, doi:10.1109/TBME.2014.2330847.2014
L. PB Meijs, L. Galeotti, E. Pueyo, D. Romero, R. B Jennings, M. Ringborn, S.G. Warren, G. S. Wagner, D. G Strauss. "An Electrocardiographic Sign of Ischemic Preconditioning" Am J Physiol Heart Circ Physiol. Vol. 307 no. H80-H87DOI: 10.1152/ajpheart.00419.2013.2014
P. Laguna, L. Sörnmo. "The STAFF III ECG Database and its Significance for Methodological Development and Evaluation" Journal of Electrocardiology, n.47; pp. 408.417 doi:10.1016/j.jelectrocard.2014.04.018.2014
M. M. Demidova, A. Martín-Yebra, J. van der Pals, S. Koul, D. Erlinge, P. Laguna, J. P. Martínez, P. G. Platonov. "Transient and rapid QRS widening associated with J-wave pattern predicts impending ventricular fibrillation in experimental myocardial infarction" Heart Rythm. n. 11; pp. 1195.1201
M. P. Bonomini, S. Corizzo, P. Laguna and P. D. Arini. "2D ECG differences in Frontal vs Preferential planes in patients referred for percutaneous transluminal coronary angioplasty" Biomedical Signal Processing, & Control, vol. 11, pp 97-106 doi: 10.1016/j.bspc.2014.01.006.2014
P. D. Arini, F. H. Baglivo, J. P. Martínez and P. Laguna. "Evaluation of Ventricular Repolarization Dispersion During Acute Myocardial Ischemia: Spatial and Temporal ECG indices" Medical & Biological Enginering & Computing, Vol. 52, n. 4, pp. 375-391, doi: 10.1007/s11517-014-1136-z.2014
J. Bolea, P. Laguna, J. M. Remartínez, E. Rovira, A. Navarro, R. Bailón. "Methodological framework for estimating the Correlation Dimension in HRV signals" Computational and Mathematical Methods in Medicine. Vol. 2014, Article ID 129248, 11 pages doi:10.1155/2014/129248.2014
M. Orini, B. Hanson, V. Monasterio, J.P. Martínez, M. Hayward, P. Taggart, P. Lambiase. "Comparative Evaluation of Methodologies for T-wave Alternans Mapping in Electrograms" IEEE Trans. on Biomedical Engineering. Vol. 61, n. 2. pp. pp. 308-316. doi: 10.1109/TBME.2013.2289304.2014
A Roebuck, V Monasterio, E Gederi, M Osipov, J Behar, A Malhotra, T Penzel, G D Clifford. "A review of signals used in sleep analysis" Physiological Measurement. vol. 35 R1.R57 doi:10.1088/0967-3334/35/1/R1.2014
J. Lázaro, E. Gil, J. M. Vergara, P. Laguna. "Pulse Rate Variability Analysis for Discrimination of Sleep-Apnea-Related Decreases in the Amplitude Fluctuations of PPG Signal in Children" IEEE Journal of Biomedical and Health Informatics, Vol. 18, n. 1, pp. 240-246. doi: 10.1109/JBHI.2013.2267096.2014
A. Bueno-Orovio, C. Sánchez, E. Pueyo, B. Rodriguez. "Na/K pump regulation of cardiac repolarization: insights from a systems biology approach" Eur J Physiol. INVITED REVIEW. 466:183.193 doi: 10.1007/s00424-013-1293-1.2014
R. Almeida, H. Gonçalves, J. Bernardes and A.P. Rocha. "Fetal QRS detection and heart rate estimation: a wavelet-based approach" Physiol. Meas. n. 35 pp. 1723.1735. doi:10.1088/0967-3334/35/8/1723.2014
J. Vicente, L. Johannesen, L. Galeotti, and D. G. Strauss, S. Spring. "Mechanisms of sex and age differences in ventricular repolarization in humans" American Heart Journal V. 168, n. 5; pp. 749-756. doi: 10.1016/j.ahj.2014.07.010.2014
M. Peláez, M. Orini, J. Lázaro, R. Bailón, E. Gil. "Cross Time-Frequency Analysis for Combining Information of Several Sources. Application to estimation of Spontaneous respiratory rate from Photoplestimography" Computational and Mathematical methods in medicine, Volume 2013, Article ID 631978, 8 pages doi:10.1155/2013/631978.2013
Santos-Lozano A, Santín-Medeiros F, Cardon G, Torres-Luque G, Bailón R, Bergmeir C, Ruiz JR, Lucia A, Garatachea N. "Actigraph GT3X: Validation and Determination of Physical Activity Intensity Cut Points" International Journal of Sports Medicine, DOI: 10.1055/s-0033-1337945.2013
V. Monasterio, J. P. Martínez, P. Laguna, S. McNitt, S. Polonsky, A.J. Moss, M. Haigney, W. Zareba, J.
P. Couderc.
"Prognostic value of average T-wave alternans and QT variability for cardiac events in MADIT-II patients" Journal of Electrocardiology, vol. 46, pp. 480-486. doi: 10.1016/j.jelectrocard.2013.08.004.
E. Gil, L. Sörnmo, J.P. Martínez, O. Baquero, A. García, P. Laguna. "Heart Rate Turbu-lence measured from Photoplethysmography" IEEE Trans. on Biomedical Engineering, Vol. 60, n.. 11, pp. 3149-3155, doi: 10.1109/TBME.2013.2270083.2013
E. Pueyo, R. Bailón, E. Gil, J. P. Martínez and P. Laguna. "Signal processing guided by physiology: making the most of cardio-respiratory signals" IEEE Signal Processing Magazine, vol.30, n.5, pp. 136-142; doi:10.1109/MSP.2013.2266961.2013
E. Pueyo. "Coronary artery disease diagnosis by analysis of ECG depolarization" Journal of Electrocardiology, vol. 46, pp. 27.28, doi:10.1016/j.jelectrocard.2012.10.016.2013
D. Romero, P. Laguna , E. Pueyo. "Detecting acute myocardial ischemai by evaluation of QRS angles" International Journal of Bioelectromagnetism vol. 15, n.1 pp. 77-82.2013
M. Demidova, A. Martin-Yebra; J.P. Martinez, V. Monasterio; S. Koul, Jesper van der Pals, D. Romero; P. Laguna, D. Erlinge, P. G. Platonov. "T-wave alternans in experimental myocardial infarction: time course and predictive value for the assessment of myocardial damage" Journal of Electrocardiology, vol. 46 pp. 263. 269. doi:10.1016/j.jelectrocard.2013.03.001.2013
D. Romero, M. Ringborn, P. Laguna and E. Pueyo. "Detection and quantification of acute myocardial ischemia by morphologic evaluation of QRS changes by an angle-based method" Journal of Electrocardiology, vol. 46 pp. 204. 214. doi:10.1016/j.jelectrocard.2013.02.014.2013
R. Bailón, N. Garatachea, I. de la Iglesia, J.A. Casajús, and P. Laguna. "Influence of running stride frequency in heart rate variability analysis during treadmill exercise testing" IEEE Trans. on Biomedical Engineering, Vol. 60, NO. 7, pp. 1796-1805, doi:0.1109/TBME.2013.2242328.2013
J. Lázaro, E. Gil, R. Bailón, A. Mincholé, and P. Laguna. "Deriving Respiration from Photoplethysmographic Pulse Width" Medical & Biological Engineering & Computing. vol. 51 pp. 233. 242. doi:10.1007/s11517-012-0954-0.2013
J. Lázaro, E. Gil, R. Bailón, A. Mincholé, and P. Laguna. "Erratum to: Deriving respiration from photoplethysmographic pulse width" Medical & Biological Engineering & Computing. 51:243 doi: 10.1007/s11517-012-0997-2.2013
E.G.Caiani, A. Pellegrini, J. Bolea, M. Sotaquira, R. Almeida, P.Vaïda. " Impaired T wave amplitude adaptation to heart-rate induced bycardiac deconditioning after 5-days of head-down bed-rest." Acta Astronautica vol. 91 pp. 166.172.

R. L. Verrier, T. Klingeheben, M. Malik, N. El-Sherif, D. V. Exner, S. H. Hohnloser, T. Ikeda, J. P. Martínez, S. Narayan, T. Nieminen, D. Rosenbaum. "Microvolt T-wave alternans testing has a role in arrhythmia risk stratification" Journal of the American College of Cardiology 59(17):1572-3. April 2012. doi: 10.1016/j.jacc.2012.03.008.2012
M. Orini, R. Bailón, P. Laguna, L. Mainardi, R. Barbieri. "A multivariate time-frequency method to characterize the influence of respiration over heart period and arterial pressure" EURASIP Journal on Advances in Signal Processing, 2012 2012:214., doi:10.1186/1687-6180-2012-214.2012
L. Sörnmo, F. Sandberg, E. Gil, K. Solem. "Noninvasive Techniques for Prevention of Intradialytic Hypotension" IEEE reviews in Biomedical Engineering. doi: 10.1109/RBME.2012.2210036.2012
V. Monasterio, F. Burgess, G. D. Clifford. "Robust classification of neonatal apnoea-related desaturations" Physiological Measurement. vol. 33, pp. 1503.1516, doi:10.1088/0967-3334/33/9/1503.2012
M. Llamedo, and J. P. Martínez. " An Automatic Patient-Adapted ECG Heartbeat Classifier allowing Expert Assistance" IEEE Trans Biomedical Enginiering, vol. 59, n. 8, doi: 10.1109/TBME.2012.2202662.2012
M. Llamedo, A. Khawaja, and J. P. Martínez. "Cross-Database Evaluation of a Multilead Heartbeat Classifier" IEEE Transactions on Information Technology in Biomedicine. vol. 16, n. 4, pp. 658-664. doi: 10.1109/TITB.2012.2193408.2012
M. Noriega, J.P. Martínez, P. Laguna, R. Bailón and R. Almeida. "Respiration effect on Wavelet-based ECG T-wave end delineation strategies" IEEE Trans Biomedical Enginiering, Vol. 59, N. 7, pp. 1818-1828 doi: 10.1109/TBME.2011.2157824.2012
V. Monasterio, P. Laguna, I. Cygankiewicz, R. Vázquez, A. Bayés-Genís, A. Bayés de Luna, JP. Martínez. "Average T-wave alternans activity in ambulatory ECG records predicts sudden cardiac death in patients with chronic heart failure" Heart Rhythm, Vol. 9, n 3, pp. 383-389. doi: 10.1016/j.hrthm.2011.10.027.2012
V. Monasterio, P. Laguna, I. Cygankiewicz, R. Vázquez, A. Bayés-Genís, A. Bayés de Luna, JP. Martínez. "Average T-wave alternans activity in ambulatory electrocardiogram records: Commentary on the relationship with T-wave amplitude and T-wave alternans regionality" Heart Rhythm, Vol 9, No 3, e6-e7, doi:10.1016/j.hrthm.2011.11.05.2012
C. Sánchez, A. Corrias, A. Bueno-Orovio M. Davies, J. Swinton, I. Jacobson, P. Laguna, E. Pueyo, B. Rodríguez. "The Na+/K+ pump is an important modulator of refractoriness and rotor dynamics in human atrial tissue" Am J Physiol Heart Circ Physiol, 302: H1146--H1159. doi:10.1152/ajpheart.00668.2011.2012
M. Orini, P. Laguna, L. Mainardi, R. Bailón. "Assessment of the dynamic interactions between heart rate and arterial pressure by cross time-frequency analysis" Physiological Measurement, vol. 33, pp. 315-331. doi:10.1088/0967-3334/33/3/315.2012
M. Orini, R. Bailón, L. Mainardi, P. Laguna. "Synthesis of HRV signals characterized by predetermined time-frequency structure by means of time-varying ARMA models" Biomedical Signal Processing and Control, vol. 7, pp. 141-150 doi:10.1016/j.bspc.2011.05.003.2012
M. Orini, R. Bailón, L. Mainardi, P. Laguna, P. Flandrin. "Characterization of the dynamic interactions between cardiovascular signals by time-frequency coherence" IEEE Trans Biomedical Engineering, vol. 59, n. 3, pp. 663-673, doi:10.1109/TBME.2011.2171959.2012
D. Romero, M. Ringborn, M. Demidova, P. Laguna, S. Koul, P. Platonov, E. Pueyo. "Characterization of Ventricular Depolarization Changes in a Porcine Model of Myocardial Infarction" Physiological measurement, vol 33 1975--1991 doi:10.1088/0967-3334/33/12/1975.2012
R. L. Verrier, T. Klingeheben, M. Malik, N. El-Sherif, D. V. Exner,, S. H. Hohnloser, T. Ikeda, J. P. Martínez, S. Narayan, T. Nieminen, D. Rosenbaum. " Microvolt T-Wave Alternans Physiological Basis, Methods of Measurement, and Clinical Utility" Consensus Guideline by International Society for Holter and Noninvasive Electrocardiology. Journal of the American College of Cardiology 2011;58:1309.1324. doi:10.1016/j.jacc.2011.06.029.2011
M. Llamedo, J. P. Martínez. "Heartbeat Classification Using Feature Selection driven by Database Generalization Criteria" IEEE Transactions on Biomedical Engineering, 2011, 58, 616-625. doi:10.1109/TBME.2010.2068048 Marzo. 2011.2011
T. Mar, S. Zaunseder, J. P. Martínez, M. Llamedo, and R. Pol. "Optimization of ECG Classification by Means of Feature Selection" IEEE Transactions on Biomedical Engineering. Vol. 58, No. 8, pp. 2168- 2177 doi: 10.1109/TBME.2011.2113395.2011
S. Nemati, O. Abdala, V. Monasterio, S. Yim-Yeh, A. Malhotra, and G.D. Clifford. "A Nonparametric Surrogate-Based Test of Significance for T-Wave Alternans Detection" IEEE Transactions on Biomedical Engineering. Vol. 58, N. 5, pp. 1356- 1364. Digital Object Identifier 10.1109/TBME.2010.2047859.2011
D. Romero, M. Ringborn, P. Laguna, O. Palhm, E. Pueyo. "Depolarization changes during acute myocardial ischemia by evaluation of QRS slopes. Standard lead and vectorial approach" IEEE Transactions on Biomedical Engineering. Vol. 58, No. 1, pp. 110-120. doi:10.1109/TBME.2010.2076385.2011
R. Bailón, G. Laouini, C. Grao, M. Orini, P. Laguna, O. Meste. "The Integral Pulse Frequency Modulation with Time-Varying Threshold: Application to Heart Rate Variability Analysis during Exercise Stress Testing" IEEE Trans. on Biomedical Engineering, VOL. 58, NO. 3, pp 642-652 10.1109/TBME.2010.2095011.2011
L.M. Sepúlveda-Cano, E. Gil, P. Laguna, G. Castellanos-Dominguez. "Selection of Non-stationary Dynamic Features for Obstructive Sleep Apnoea Detection in Children" EURASIP Journal on Advances in Signal Processing, Volume 2011, ISSN 1687-6172 Article ID 538314, 10 pages doi:10.1155/2011/538314.2011
A. Mincholé, E. Pueyo, J.F. Rodríguez, E. Zacur, M. Doblaré and P. Laguna. "Quantification of Restitution Dispersion from the Dynamic Changes of the T wave peak to end, measured at the Surface ECG" IEEE Trans Biomedical Enginiering, Vol. 58, n. 5, pp. 1172-1182. doi:10.1109/TBME.2010.2097597.2011
R. Bailón, P. Serrano, P. Laguna. "Influence of time-varying mean heart rate in coronary artery disease diagnostic performance of heart rate variability indices from exercise stress testing" Journal of Electrocardiology, vol.44, pp. 445.452, doi:10.1016/j.jelectrocard.2011.02.001.2011
M. Ringborn, D. Romero, E. Pueyo, O. Pahlm, G.S. Wagner, P. Laguna and P.G. Platonov. "Evaluation of depolarization changes during acute myocardial ischemia by analysis of QRS slopes" Journal of Electrocardiology, vol. pp. 44 416--424 doi:10.1016/j.jelectrocard.2011.03.005.2011
J. Carro, J.F. Rodríguez, P. Laguna, and E. Pueyo. "A human ventricular cell model for investigation of cardiac arrhythmias under hyperkalemic conditions" Phil Trans Royal Soc A, n. 369, pp. 4205-4232, doi: 10.1098/rsta.2011.0127.2011
E. Pueyo A. Corrias, L. Virág, N. Jost, T. Szel, A. Varró, N. Szentandrássy, P. Nánási, K. Burrage, B. Rodríguez. "A multi-scale investigation of repolarization variability and its role in cardiac arrhythmogenesis" Biophys J, Vol. 101(12), p.2892-2902. doi:10.1016/j.bpj.2011.09.060.2011
D. Abramson, M. Bernabeu, B. Bethwaite, K. Burrage, E. Pueyo, B. Rodríguez, A. Sher, K. Tan. " High-throughput cardiac science on the grid" Philosophical Transactions of the Royal Society - A. Vol. 368, pp.3907-3923. May .2010..2010
A. Corrias, X. Jie, L. Romero, M. Bishop, M Bernabeu, E. Pueyo, B. Rodríguez. "Arrhythmic Risk Biomarkers for the Assessment of Drug Cardiotoxicity: from experiments to computer simulations" Philosophical Transactions of the Royal Society - A, Vol. 368, pp.3001-3025.2010
D. Smith, K. Solem, P. Laguna, J. P. Martínez, L. Sörnmo. "Model-based Detection of Heart Rate Turbulence Using Mean Shape Information" IEEE Transactions on Biomedical Engineering, Vol. 57, n. 2, pp. 334-342.2010
A. Mincholé, F. jager, P. Laguna. "Discrimination Between Ischemic and Artifactual ST Segment Events in Holter Recordings" Biomedical signal processing and control, Vol. 5 pp. 21-31 doi:10.1016/j.bspc.2009.09.001.2010
E. Gil, R. Bailón, J. M. Vergara, P. Laguna. "PTT variability for discrimination of sleep apnea related decreases in the amplitude fluctuations of PPG signal in children" IEEE Transaction on Biomedical Engineering, vol. 57, n. 5, pp. 1079-1088, doi:10.1109/TBME.2009.2037734.2010
M. Orini, R. Bailón, R. Enk, S. Koelsch, L. Mainardi, P. Laguna. "A method for continuously assessing the autonomic response to music-induced emotions through HRV analysis" Medical and Bilogical Engineering and Computing, 48, pp.423.433, DOI: 10.1007/s11517-010-0592-3.2010
E. Pueyo, Z. Husti, T. Hornyik, I.Baczkó, P. Laguna, A. Varró, B. Rodríguez. "Mechanisms of ventricular rate adaptation as a predictor of arrhythmic risk" American Journal of Physiology, vol. 298, pp H1577-H1587, doi:10.1152/ajpheart.00936.2009.2010
V. Monasterio, G. D. Clifford, P. Laguna, J. P. Martínez. "A Multilead Scheme based on Periodic Component Analysis for T Wave Alternans Analysis in the ECG" Annals of Biomedical Engineering, Vol. 38, No. 8, pp. 2532.2541; doi: 10.1007/s10439-010-0029-z.2010
M. Orini, R. Bailón, E. Gil, L. Minardi, P. Laguna. "Framework for continuous quantification of spectral Coherence using Quadratic Time-Frequency distributions: exploring cardiovascular coupling" International Journal of Bioelectromagnetism, , Vol. 12, No. 4, pp. 177-182.2010
E. Gil, J.M. Vergara, and P. Laguna. "Pulse Transit Time Variability versus Heart Rate Variability during Decreases in the Amplitude fluctuations of Photoplethysmography signal" International Journal of Bioelectromagnetism, Vol. 12, No. 3, pp. 95 - 101.2010
E. Gil, M. Orini, R. Bailón, J.M. Vergara, L. Mainardi and P.Laguna. "Photoplethysmography pulse rate variability as a surrogate measurement of heart rate variability during non-stationary conditions" Physiological Measurement, vol. 31, pp. 1271-1290 , doi:10.1088/0967-3334/31/9/015.2010
J. P. Martínez, I. Cygankiewicz, D. Smith, A. Bayés de Luna, P. Laguna and L. Sörnmo. "Detection performance and risk stratification using a model-based shape index characterizing heart rate turbulence" Annals of Biomedical Engineering, Vol. 38, No. 10, pp. 3173-3184.2010
R. Bailón, L. Mainardi, M. Orini, L. Sörnmo and P. Laguna. "Analysis of heart rate variability during exercise stress testing using respiratory information" Biomedical Signal Processing and Control, vol. 5, pp. 299.310, doi:10.1016/j.bspc.2010.05.005.2010
L. Romero, E. Pueyo, M. Fink, B. Rodríguez. "Impact of ionic current variability on human ventricular cellular electrophysiology" American Journal of Physiology. Vol. 297, pp. 1436-14452009
E. Gil, M. Mendez, J.M. Vergara, S. Cerutti, A. M. Bianchi, P. Laguna. "Discrimination of sleep apnea related decreases in the amplitude fluctuations of PPG signal in children by HRV" IEEE Trans. on Biomedical Engineering, vol. 56, n.. 4, pp. 1005-1014.2009
Laguna P., Sörnmo L. "Introduction. Editorial on "Signal processing in vital rhythms and signs"" Special issue on Signal processing in vital rhythms and signs, Transactions of the Royal Society A, vol. 367, pp. 207.211. doi:10.1098/rsta.2008.0239.2009
E. Pueyo, J. P. Martínez, P. Laguna. "Cardiac repolarisation analysis using the surface ECG" Philosophical Transactions of the Royal Society - A. vol. 367, pp. 213.233.doi:10.1098/rsta.2008.0230.2009
V. Monasterio, P. Laguna and J.P. Martínez. "Multilead Analysis of T Wave Alternans in the ECG using Principal Component Analysis" IEEE Trans. on Biomedical Engineering, vol.56, no.7, pp.1880-1890. doi:10.1109/TBME.2009.2015935.2009
R. Almeida, J.P. Martínez, A.P. Rocha and P. Laguna. "Multilead ECG delineation using spatially projected leads from wavelet transform loops" IEEE Trans. on Biomedical Engineering, vol. 56, no. 8, pp. 1996-2005, doi:10.1109/TBME.2009.2021658.2009
S. Gouveia, A. P. Rocha A. P., P. Laguna and P. Lago. "Time domain baroreflex sensitivity assessment by joint analysis of spontaneous SBP and RR series" Biomedical signal processing and control. vol. 4, pp. 254-261 doi:10.1016/j.bspc.2009.03.003.2009
M. Mendez, A. M. Bianchi, N. Montano, V. Patruno, E. Gil, C Mantaras, S Aiolfi, S. Cerutti. "On arousal from sleep: time-frequency analysis" Medical Biological Engineering Computing, vol. 46, pp. 341-351.2008
Pueyo E., Sörnmo L., y Laguna P. "QRS Slopes for Detection and Characterization of Myocardial Ischemia" IEEE Trans. on Biomedical Engineering, vol. 55, n. 2, pp. 468-568. 10.1109/TBME.2007.902228.2008
E. Pueyo, M. Malik, P. Laguna. "A dynamic model to characterize beat-to-beat adaptation of repolarization to heart rate changes" Biomedical signal processing and control, Elsevier., vol. 3 pp. 29-43; doi:10.1016/j.bspc.2007.09.005.2008
P.D. Arini, G.C. Bertrán, E.R. Valverde, y P. Laguna. "T-wave Width as an Index for Quantification of Ventricular Repolarization Dispersion: Evaluation in an Isolated Rabbit Heart Model" Biomedical signal processing and control, Elsevier. vol. 3, pp. 67-77 doi:10.1016/j.bspc.2007.10.001.2008
E. Gil, J.M. Vergara, P. Laguna. "Detection of decreases in the amplitude fluctuation of pulse photoplethysmography signal as indication of Obstructive Sleep Apnea Syndrome in children" Biomedical signal processing and control, Elsevier, doi:10.1016/j.bspc.2007.12.002.2008..2008
K. Solem, P. Laguna, J. P. Martínez, L. Sörnmo. "Model-based Detection of Heart Rate Turbulence" IEEE Trans. on Biomedical Engineering, Vol. 55, n. 12, pp. 2712-2722 doi:10.1109/TBME.2008.2002113.2008
J.P. Martínez, P. Laguna, S. Olmos, O. Pahlm, J. Pettersson, L. Sörnmo. "Assessment of QT measurement accuracy using the 12-lead ECG derived from EASI leads Journal of Electrocardiology. vol.40, n.2, pp. 172-179.2007
F. Castells, P. Laguna, L. Sörnmo, A. Bollmann, and J. Millet. "Principal Component Analysis in ECG Signal Processing" EURASIP Journal on Advances in Signal Processing, vol. 2007, Article ID 74580, 21 pages, 2007. doi:10.1155/2007/74580.2007
W. Sandham, D. Hamilton, P. Laguna and M. Cohen. "Editorial. Advances in Electrocardiogram Signal Processing and Analysis" EURASIP Journal of Applied signal processing, vol. 2007, Article ID 69169 , 5 pages, 2007. doi:10.1155/2007/69169.2007
E. Pueyo, E. Laciar, E. Anzuola, P. Laguna and R. Jané. "QRS slopes for assessment of myocardial damage in chronic chagasic patients" Journal of Physics: Conference Series 90. 012077 doi:10.1088/1742-6596/90/1/012077.2007
L. Sörnmo, P. Laguna. "Electrocardiogram (ECG) Signal Processing" in Wiley Encyclopedia of Biomedical Engineering, Metin Akay (Editor), Volume 2, pages 1298-1313. (2006) Wiley. ISBN: 0-471-24967-X (CL).2006
R. Bailón, L. Sörnmo, P. Laguna. "ECG-derived respiratory frequency estimation" In F. Azuaje GD. Clifford and PE. McSharry, editors, Advanced methods and tools for ECG data analysis. pp. 215 -- 244. Artech House, Inc..2006
R. Bailón, L. Sörnmo, P. Laguna. "A robust method for ECG-based estimation of the respiratory frequency during stress testing" IEEE Transactions on Biomedical Engineering, vol. 53, n.7, pp. 1273-1285.2006
K. Solem, P. Laguna, L. Sörnmo. "An Efficient Method for Handling Ectopic Beats Using The Heart Timing Signal" IEEE Transaction on Biomedical Engineering, vol. 53, n. 1. pp. 13-20.2006
J.P. Martínez, S. Olmos, G. Wagner, P. Laguna. "Characterization of repolarization alternans during ischemia: time-course and spatial analysis" IEEE Transactions on Biomedical Engineering. vol. 53, n. 4, pp.701-711.2006
R. Almeida, S. Gouveia, A.P. Rocha, E. Pueyo, J.P. Martínez, P. Laguna. "QT variability and HRV interactions in ECG: Quantification and Reliability" IEEE Trans. on Biomedical Engineering, vol. 53, n.7, pp. 1317-1329.2006
L. Sörnmo, P. Laguna. "Biomedical Signal Processing in Cardiac & Neurological Applications" Academic Press, Elsevier..2005
P. Laguna, L. Sörnmo. "Biomedical Signal Processing in Cardiac & Neurological Applications. Solutions Manual" Academic Press, Elsevier.2005
J.P. Martínez, S. Olmos. "Methodological principles of T wave alternans analysis: A unified framework" IEEE Transactions on Biomedical Engineering. Vol. 52, n. 4, pp. 599-613.2005
J.P. Martínez, R. Almeida, S. Olmos, A.P. Rocha, P. Laguna. "A Wavelet-Based ECG Delineator: Evaluation on Standard Database" IEEE Trans. on Biomedical Engineering, vol. 51, n. 4, pp. 570-581.2004
Pueyo E., García J., Wagner G., Bailón R., Sörnmo L. y Laguna P. "Time course of ECG Depolarization and Repolarization changes during Ischemia in PTCA recordings" Methods Inf. Med., vol. 43, pp. 43-46.2004
E. Pueyo, P. Smetana, P. Caminal, A. Bayes de Luna, M. Malik y P. Laguna. "Characterization of QT Interval Adaptation to RR Interval Changes and Its Use as a Risk-Stratifier of Arrhythmic Mortality in Amiodarone-Treated Survivors of Acute Myocardial Infarction" IEEE Trans. on Biomedical Engineering, vol. 51, n. 9, pp. 1511-1520.2004
P. Smetana, E. Pueyo, K. Hnatkova, V. Batchvarov, P. Laguna, M. Malik. "Individual patterns of dynamic QT/RR relationship in survivors of acute myocardial infarction and their relationship to antiarrhythmic efficacy of amiodarone" Journal of Cardiovascular Electrophysiology., vol. 15, n.10, pp. 1147-1154.2004
E. Pueyo, P. Smetana, P. Laguna y M. Malik. "Assessment of individual QT/RR relationship and hysteresis in post-infarction patients" Italian Heart Journal, vol. 5, Suppleemnt n.1, pp. 165S-168S.2004
P. Smetana, E. Pueyo, K. Hnatkova, M. Malik. "Circadian patterns of QTc Interval.. Chapter of the book 'Dynamic Electrocardiography'" Blackwell Futura Publishing. Editors: M. Malik y A. J. Camm. 2004.2004
Mateo J. y Laguna P. "Analysis of Heart Rate Variability in the Presence of Ectopic Beats Using the Heart Timing Signal" IEEE Trans. on Biomedical Engineering, vol. 50, n. 3, pp. 334-343.2003
Aström M., García J., Laguna P., Pahlm O., y Sörnmo L. "Detection of body position changes using the surface Electrocardiogram" Medical and Biological Engineering and Computing, vol. 41, n. 2, pp. 164-171.2003
Leanderson S., Laguna P. y Sörnmo L. "Estimation of the respiratory frequency using spatial information in the VCG" Medical Engineering & Physics vol. 25, pp. 501.507.2003
García J., Aström M., Mendive J., Laguna P. y Sörnmo L. "ECG-based detection of body position changes in ischemia monitoring" IEEE Transactions on Biomedical Engineering, vol. 50 n. 6 , pp: 677 - 685.2003
Bailón R., Mateo J., Olmos S., Serrano P., García J., del Río A., Ferreira I.J., y Laguna P. "Coronary Artery Disease Diagnosis Based on Exercise ECG Indexes from Repolarisation, Depolarisation and Heart Rate Variability" Medical and Biological Engineering and Computing. vol. 41, pp. 561-571.2003
Pueyo E., Smetana P., Laguna, P., y Malik M. "Estimation of the QT/RR hysteresis lag" Journal of Electrocardiology, Supplement, vol 36, n. 4, pp: 187-190.2003
P. Smetana, E. Pueyo, K. Hnatkova, V. Batchvarov, A. J. Camm, M. Malik. "Effect of amiodarone on the descending limb of the T wave" American Journal of Cardiology, vol.92, pp. 742-746.2003
P. Laguna. "Synopsis on signal processing papers of the yearbook on medical informatics" Guess editor and invited synopsis, Yearbook of Medical Informatics 02, IMIA. Schattauer Publishing Company, Stuttgart. pp. 427-430.2002
S. Olmos, L. Sörnmo and P. Laguna. "Block adaptive filters with deterministic reference inputs for event related signals: BLMS and BRLS" IEEE Trans. on Signal Proc., vol. 50. n. 5, pp. 1102-1112.2002
J. García, I. Martínez, L. Sörnmo, S. Olmos, A. Mur, and P. Laguna. "Remote Processing Server for ECG-Based Clinical Diagnosis Support" IEEE Trans. on Information Technology, vol. 6. n. 4, pp. 277-284.2002
J. García, G. Wagner, L. Sörnmo, P. Lander and P. Laguna. "Identification of the occluded artery in patients with myocardial ischemia induced by prolonged PTCA using traditional vs. transformed ECG-based indexes" Selected paper from Computers and Biomedical Research Vol. 32 No. 5 Oct. pp. 470-482. in the Yearbook of Medical Informatics 01, section 4: Image and signal processing, IMIA. Schattauer Publishing Company, Stuttgart. pp. 401-413.2001
L. Sörnmo, M. Aström, E. Carro, M. Stridh, P. Laguna. "Nonlinear estimation of respiratory-induced heart movements and its application in ECG/VCG signal processing" Nonlinear Biomedical Signal Processing; Vol. II, Dynamic analysis and modeling; IEEE Press series on biomedical engineering, Metin Akay series editor. pp. 228-245.2001
García J., Wagner G., Sörnmo L., Olmos S., Lander P., Laguna P. "Temporal evolution of traditional versus transformed ECG-based indexes in patients with induced myocardial ischemia" Journal of Electrocardiology, vol. 33, n. 1. pp. 37-47.2000
Aström M., Carro E., Sörnmo L., Laguna P., Wohlfart B. "Vectocardigraphic loop alignment and the measurement of morphologic beat-to-beat variability in noisy signal" IEEE Trans. on Biomedical Engineering, vol. 47, n. 4, pp. 497-506.2000
Mateo J. and Laguna P. "Improved heart rate variability signal analysis from the beat occurrence times according to the IPFM model" IEEE Trans. on Biomedical Engineering, vol. 47, n. 8, pp. 985-996.2000
S. Olmos, P. Laguna. "Steady-satte MSE Convergence of LMS Adaptive Filters with Deterministic Reference Inputs, with applications to Biomedical Signals" IEEE Trans. on Signal Proceesing, vol. 48, n. 8, pp. 2229-2241.2000
P. Laguna, L. Sörnmo. "Sampling Rate and the Estimation of Ensemble Variability for Repetitive Signals" Medical and Biological Engineering and Computing, vol. 38, n. 5, pp. 540-546.2000
García J., Sörnmo L., Olmos S. and Laguna P. "Automatic detection of ST-T complex changes on the ECG using filtered RMS difference series: Application to ambulatory ischemia monitoring" IEEE Trans. on Biomedical Engineering, vol. 47, n. 9, pp. 1195-1201.2000
P. Laguna, G.B. Moody, J. García, A.L. Goldberger and R.G. Mark. "Analysis of the ST-T Complex Using The KL Transform: Adaptive Monitoring and Alternans Detection" Medical and Biological Engineering and Computing. Vol 37, pp. 175-189.1999
J. García, G. Wagner, L. Sörnmo, P. Lander and P. Laguna. "Identification of the occluded artery in patients with myocardial ischemia induced by prolonged PTCA using traditional vs. transformed ECG-based indexes" Computers and Biomedical Research Vol. 32 No. 5 Oct. pp. 470-482.1999
S. Olmos, J. García, R. Jané and P. Laguna. "ECG signal compression plus noise filtering with truncated orthogonal expansions" Signal Processing Vol. 79, pp. 97-115.1999
S. Olmos, J. García, R. Jané and P. Laguna. "Truncated Orthogonal expansions of recurrent signals: equivalence to a periodic time-variant filter" IEEE Trans. on Signal Proceesing, vol. 47, n. 11, pp. 3164-3172.1999
P. Laguna, G. B. Moody and R.G. Mark. "Power Spectra Density of Unevenly Sampled Data by Least-Square Analysis: Performance and Application to Heart Rate Signals" IEEE Trans. on Biomedical Engineering Vol. 45, No. 6. June. pp. 698-715.1998
J. García, P. Lander, L. Sörnmo, S. Olmos, G. Wagner and P. Laguna. "Comparative Study of Local and Karhunen-Loeve--Based ST-T Indexes in Recordings from Human Subjects with Induced Myocardial Ischemia" Computers and Biomedical Research Vol. 31 No. 4 August. pp. 271-292.1998
P. Laguna, J. García, I. Roncal, G. Wagner, P. Lander and R.G. Mark. "Model-based estimation of cardiovascular repolarization features: ischaemia detection and PTCA monitoring" J. Medical Eng. and Technology, vol. 22, n. 2, pp. 64-72.1998
E. Homs, V. Marti, J. Guindo, P. Laguna, X. Viñolas, P. Caminal, R. Elosua, and A. Bayés de Luna. "Automatic measurement of corrected QT interval in Holter recordings: Comparison of its dynamic behavior in patients after myocardial infarction with and without life-threatening arrhythmias" American Heart Journal. Vol. 134. pp. 181-1871997
P. Laguna, R. Jané, E. Masgrau and P. Caminal. "The Adaptive Linear Combiner with a Periodic-Impulse Reference Input as a Linear Comb Filter" Signal Processing Vol. 48, n. 3, pp. 193-203.1996
P. Laguna, R. Jané, S. Olmos, N.V. Thakor, H. Rix and P. Caminal. "Adaptive estimation of QRS complex by the Hermite model for classification and ectopic beat detection" Medical and Biological Engineering and Computing.vol. 34, pp. 58-68.1996
P. Laguna, G. B. Moody, R. Jané, P. Caminal and R.G. Mark. "The KL transform as a tool to analyze the ST segment: Comparison with QT interval" Journal of Electrocardiology vol. 28 (Suplement) pp. 41-49.
P. Laguna, R. Jané and P. Caminal. "Automatic detection of wave boundaries in multilead ECG signals: Validation with the CSE database" Computers and Biomedical Research, vol. 27, pp.45-60.1994
P. Laguna, R. Jané and P. Caminal. "A time delay estimator based on the signal integral: Theoretical performance and testing on ECG signals" IEEE Trans. on Signal Processing vol. 42 nº11 pp. 3224- 3229.1994
N.V. Thakor, G. Xing-rong, A. Christopher, P. Laguna, R. Jané, P. Caminal, H. Rix and D.F. Hanley "Orthonormal (Fourier and Walsh) models of time-varying evoked potentials in neurological injury" IEEE Trans. on Biomedical Engineering vol. 40, n.3 pp.213-221.1993
P. Laguna, R.Jané, O. Meste, P.W. Poon, P. Caminal, H. Rix, N.V. Thakor. "Adaptive filter for event-related bioelectric signals using an impulse correlated reference input: Comparison with signal averaging techniques" IEEE Trans. on Biomedical Engingering, vol. 39, n. 10. pp. 1032-1044.1992
Laguna P., P. Caminal, R. Jané y N.V. Thakor Journal of Ambulatory Monitoring. vol. 4, n. 2 . pp 91-111.1991
Jané R., H. Rix, P. Caminal y P. Laguna IEEE Trans. on Biomedical Engineering, vol. 34, n. 6, pp. 571-579.1991
Laguna P., N.V. Thakor, P. Caminal, y R. Jané. IEEE Trans. on Biomedical Engineering, vol. 37, n. 4, pp. 420-424.1990
Laguna P., N.V. Thakor, P. Caminal, R. Jané, H.R. Yoon Medical and Biological Engineering and Computing, 28, pp. 67-731990

Ph.D. Thesis

Ph.D. ThesisYear
J. Bolea "Novel Framework for Nonlinear HRV Analysis and its Physiological Interpretation." Zaragoza University2018
J. Ramirez "Prediction of Cardiac Death Risk by Analysis of Ventricular Repolarization Restitution from the Electrocardiogram Signal" Zaragoza University2017
D. Hernando "Non-Invasive Assessment of Autonomic Nervous System through Cardiovascular Signals Variability Analysis in Non-Stationary Environments" Zaragoza University2017
A. Martín "Assessment of ventricular repolarization instability and cardiac risk stratification in different pathological and abnormal conditions" Politecnico Milano / Zaragoza University2017
A. Alcaine "Intracardiac Signal Processing for Mapping and Characterising Cardiac Arrhythmias." Zaragoza University2016
J. Vicente "Novel Electrocardiographic Biomarkers for Proarrhythmic Assessment of Drugs." Zaragoza University2016
Lázaro, J. "Non-invasive techniques for respiratory information extraction based on pulse photoplethysmogram and electrocardiogram" Zaragoza University2015
Sánchez, C. "Multiscale Analysis of Atrial Fibrillation Mechanisms" Zaragoza University.
Romero D. "Characterization, detection and quantification of acute myocardial ischemia from depolarization ECG-derived indices" Zaragoza University.2013
Llamedo M. "Signal Processing for Automatic Heartbeat Classification and Patient Adaptation in the Electrocardiogram" Zaragoza University.2012
Mincholé A. "Automatic detection of ischemia in Holter recordings and search for new risk markes from the electrocardiographic signal" Zaragoza University.2011
Monasterio V. "Multilead analysis of T-wave alternans in the electrocardiogram" Zaragoza University.2011
Orini M. "Time-frequency analysis for the dynamic quantification of the interactions between signals related to the cardiovascular system." Zaragoza University/Politecnique of Milan.2011
E. Gil "Análisis multimodal de las señales fotopletismográfica de pulso y electrocardiográfica para el diagnóstico del síndrome de apnea obstructiva durante el sueño en niños" Zaragoza University.2009
S. Gouveia "Contributions to the analysis of short term cardiovascular coupling" Porto University, Portugal.2009
P.D. Arini "Estudio y cuantificación de la dispersión de la repolarización ventricular cardiaca a través de la onda T en la señal electrocardiográfica" Zaragoza University.2007
R. Bailón "Análisis de la señal electrocardiográfica durante prueba de esfuerzo y su aplicación en el diagnóstico de cardiopatías" Zaragoza University.2006
E. Pueyo "Detección de heterogeneidades en la depolarización y repolarización cardiacas a partir del electrocardiograma como mejora en la predicción del riesgo frente a arritmias" Zaragoza University.2006
R. Almeida "Automatic ECG characterization: Application to QT interval variability" University of Porto.2006
J.P. Martinez "Análisis de alternancias de onda T en la señal electrocardiográfica" Zaragoza University.2005
Mateo J. "Análisis de la variabilidad del ritmo cardiaco: Análisis temporal e índices clínicos". Zaragoza University2000
Olmos S. Compresión de datos en señales ECG mediante transformadas ortogonales. Zaragoza University/Universidad Politécnica de Cataluña1998
Garcia J. "Sistema de Monitorización y Detección de Isquemia Basado en la Transformada de Karhunen-Loève Aplicada sobre el ECG" Zaragoza University.1998
Laguna P. " Nuevas técnicas de procesado de señales electrocardiográficas: aplicación a registros de larga duración." Politecnique University of Catalunya / Zaragoza University.

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