Esther Pueyo Paulés

esther-pueyo2

ESTHER PUEYO PAULES

Esther Pueyo received the M.S. degree in Mathematics from the University of Zaragoza, Spain, in 1999. During 2000, she was a research student at the Department of Mathematics, University of Zaragoza, where she developed a minor thesis in the field of Calculus, supervised by Prof. José Garay. In 2001 she started her Ph.D. studies in Biomedical Engineering at the University of Zaragoza under the supervision of Prof. Pablo Laguna, with a grant supported by the Spanish government. Her Ph.D. studies aimed at developing signal processing techniques applied to the electrocardiogram with the purpose of investigating conditions predisposing to suffer cardiac arrhythmias. During that time, she also worked as an Assistant Professor of Signal Processing at the Department of Electronic Engineering and Communications and she was a visiting scholar at research centers in Portugal, Argentina and UK, with long research visits at St. George’s Hospital Medical School, London, UK, where she worked under the supervision of Prof. Marek Malik.

After finishing her PhD in December 2006, she moved to the University of Oxford, UK (2007-2009) to get postdoctoral training in computational modeling and simulation of cardiac electrophysiology. She worked with Dr. Blanca Rodríguez and Prof. Kevin Burrage in the construction of cell and tissue models to investigate cardiac pathologies and drug-induced effects associated with increased arrhythmic risk. Most of the studies conducted during her postdoctoral period involved collaborations with experts in cardiology and experimental physiology, mainly from Hungary, UK and Sweden.

In January 2011 she was appointed Associate Professor at the University of Zaragoza, Spain. During 2012-2015 she worked as Senior Researcher at the Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) after having been awarded with a ‘Ramón y Cajal’ Senior Research fellowship by the Spanish government. At the University of Zaragoza and CIBER-BBN, she works with a group of postdoctoral researchers and PhD, MSc and undergraduate students in the development of methodologies for the analysis of simulated, experimental and clinical data. By combining ECG signal processing and electrophysiological modeling and simulation tools, her current research aims at shedding light on the mechanisms and manifestations of cardiac arrhythmias at scales ranging from cellular ion channels to the electrocardiogram and on the role of important modulators such as the Autonomic Nervous System.

Since October 2015 she is back to her Associate Professor position at the University of Zaragoza. She has participated as Principal Investigator and as Collaborator in different international, European, national and regional research projects. She is currently PI of the ERC Starting Grant project MODELAGE, funded with 1.5 M€, in which a systems biology approach is used to investigate the aging of the human heart.


CONTACT:

         Address: C/Mariano Esquillor s/n, 50018, Zaragoza (Spain)

         Phone: +34 976 762963

         E-Mail: epueyo@unizar.es

         WEB: http://www.estherpueyo.com

117 registros « 2 de 3 »

Conferencias

2015

Vicente, J; Johannesen, L; Mason, J W; Crumb, W J; Pueyo, E; Stockbridge, N; Strauss, D G

Comprehensive Analysis of Novel Electrocardiographic Device Algorithms for Differentiating Arrhythmic Risk Conferencia

FDA Science Forum, Silver Spring, MD, 2015.

BibTeX

Vicente, J; Johannesen, L; Mason, J W; Pueyo, E; Stockbridge, N; Strauss, D G

Sex Differences in Drug-Induced Changes in Ventricular Repolarization Conferencia

International Society of Computerized Electrocardiology, San Jose, California, US, 2015.

BibTeX

Caiani, E G; Martín-Yebra, A; Pellegrini, A; Bolea, J; Auricchio, A; Pueyo, E; Vaida, P

High protein intake supplementation to compensate changes in ventricular repolarization due to 21-days of bedridden immobilization Conferencia

ESC; European Heart Journal, 2015.

BibTeX

2014

Valenza, G; Orini, M; Citi, L; Minchole, A; Pueyo, E; Laguna, P; Barbieri, R

Assessing Instantaneous QT Variability dynamics within a Point-Process Nonlinear Framework Conferencia

8th CONFERENCE OF THE EUROPEAN STUDY GROUP ON CARDIOVASCULAR OSCILLATIONS, 2014.

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Bolea, J; Pueyo, E; Laguna, P; Bailón, R

Non-linear HRV indices under autonomic nervous system blockade Conferencia

36nd Annual International Conference of the IEEE EMBS, 2014.

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Valenza, G; Orini, M; Citi, L; Minchole, A; Pueyo, E; Laguna, P; Barbieri, R

Assessing Real-Time RR-QT Frequency-Domain Measures of Coupling and Causality through Inhomogeneous Point-Process Bivariate Models Conferencia

36nd Annual International Conference of the IEEE EMBS, 2014.

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Carro, J; Rodríguez, J F; Pueyo, E

In Silico Simulations of Experimental Protocols for Cardiac Modeling Conferencia

36nd Annual International Conference of the IEEE EMBS, 2014.

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Romero, D; Behar, N; Martín-Yebra, A; Martínez, J P; Laguna, P; Pueyo, E; Carrault, G; Mabo, P; Hernández, A

Analysis of QRS Alterations during Stress Test Recordings on Patients with Brugada Syndrome Conferencia

XLI International Conference on Computing in Cardiology, 2014.

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Ramírez, J; Cygankiewicz, I; Laguna, P; Malik, M; Pueyo, E

Circadian Pattern and Sex Differences of QT/RR and T-peak-to-end/RR Curvatures and Slopes in Chronic Heart Failure Patients Conferencia

XLI International Conference on Computing in Cardiology, 2014.

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Romero, D; Martínez, J P; Laguna, P; Pueyo, E

Detection of Acute Ischemia Episodes from QRS Angles Changes using a Laplacian Noise Model Conferencia

XLI International Conference on Computing in Cardiology, 2014.

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Vicente, J; Johannesen, L; Afoakwa, R K; Pueyo, E; Stockbridge, N; Mason, J W; Strauss, D G

T wave Morphology Assessment in a Randomized Double-blind Crossover Study of Four hERG Potassium Channel Blocking Drugs Conferencia

Circulation, 130 (Suppl 2), 2014.

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Monasterio, V; Carro, J; Pueyo, E

Repolarization alternans in human ventricular hyperkalaemic tissue: dependence on current stimulation Conferencia

Proceedings XXXII Congreso Anual de la Sociedad Española de Ingeniería Biomédica, 2014, ISBN: 978-84-617-2446-8.

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Ramírez, J; Laguna, P; Pueyo, E

Modulación Circadiana y de Género de las Relaciones QT/RR y T-pico-a-fin/RR en Pacientes con Insuficiencia Cardiaca Conferencia

Proceedings XXXII Congreso Anual de la Sociedad Española de Ingeniería Biomédica, 2014, ISBN: 978-84-617-2446-8.

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2013

Sánchez, C; Bueno-Orovio, A; Pueyo, E; Rodriguez, B

Cell Repolarization Variability Modulates Atrial FibrillationDynamics in 3D Virtual Human Atria Conferencia

XL International Conference on Computing in Cardiology, Zaragoza, Spain, 2013.

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Rodriguez, J F; Sassi, R; Pueyo, E; Mainardi, L

Repolarization Variability Mechanisms and its Relation with Cardiac Arrhytmogenesis Conferencia

XL International Conference on Computing in Cardiology, Zaragoza, Spain, 2013.

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Llamedo, M; Martínez, J P; Albertal, M; Romero, D; Pueyo, E; Laguna, P

Morphologic Features of the ECG for Detection of Stress-Induced Ischemia Conferencia

XL International Conference on Computing in Cardiology, Zaragoza, Spain, 2013.

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Hernando, D; Alcaine, A; Pueyo, E; Laguna, P; Orini, M; Arcentales, A; Giraldo, B; Voss, A; Bayés-Genís, A; Bailón, R

Influence of Respiration in the Very Low Frequency Modulation of QRS slopes and Heart Rate Variability in Cardiomyopathy Patients Conferencia

XL International Conference on Computing in Cardiology, Zaragoza, Spain, 2013.

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Ramírez, J; Mincholé, A; Bolea, J; Laguna, P; Pueyo, E

Prediction of Sudden Cardiac Death in Chronic Heart Failure Patients by Analysis of Restitution Dispersion Conferencia

XL International Conference on Computing in Cardiology, Zaragoza, Spain, 2013.

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Hernando, D; Alcaine, A; Laguna, P; Pueyo, E; Bailón, R

Very low frequency modulation in QRS slopes and its relation with respiration and heart rate variability during hemodialysis Conferencia

35nd Annual International Conference of the IEEE EMBS, Osaka, Japan, 2013.

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2012

Romero, D; Laguna, P; Pueyo, E

Detecting acute myocardial ischemia by evaluation of QRS angles Conferencia

BSI12, 2012.

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Minchole, A; Zacur, E; Pueyo, E; Laguna, P

Efficient characterization of repolarization adaptation to heart rate changes Conferencia

BSI12, 2012.

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Minchole, A; Bueno-Orovio, A; Laguna, P; Pueyo, E; Rodriguez, B

A novel ECG-based biomarker quantifying apd restitution dispersion improves risk stratification following sotalol administration Conferencia

BSI12, 2012.

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Bolea, J; Caiani, E G; Pueyo, E; Laguna, P; Almeida, R

Microgravity effects on ventricular response to heart rate changes Conferencia

34nd Annual International Conference of the IEEE EMBS, San Diego, USA, 2012.

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Sánchez, C; Krueger, M W; Seemann, G; Dössel, O; Pueyo, E; Rodriguez, B

Ionic Modulation of Atrial Fibrillation Dynamics in a Human 3D Atrial Model Conferencia

XXXIX International Conference on Computing in Cardiology, Kracow, Poland, 2012.

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Ramírez, J; Mincholé, A; Laguna, P; Pueyo, E

Characterization of Cardiac Repolarization Response to Heart Rate Changes Provoked by a Tilt Test Conferencia

XXXIX International Conference on Computing in Cardiology, Kracow, Poland, 2012.

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Meijs, L P B; Galeotti, L; Pueyo, E; Romero, D; Jennings, R B; Wagner, G S; Strauss, D G

Increased T-amplitude with decreased ST-elevation characterizes ischemic preconditioning: A Simulation, Experimental and Clinical Study Conferencia

ISCE 2012 Annual Meting, Harrisburg, USA, 2012.

BibTeX

Sánchez, C; Bueno-Orovio, A; Pueyo, E; Rodriguez, B

Analysis of Populations of Human Atrial Models Reveals the Relative Importance of Ionic Conductances in the Different Stages of Repolarization Conferencia

36th meeting of the European Working Group of Cardiac Cellular Electrophysiology, Nantes, France, 2012.

BibTeX

Ramírez, J; Mincholé, A; Laguna, P; Pueyo, E

Caracterización de la Respuesta de la Repolarización a Cambios en el Ritmo Cardiaco Provocados por una Prueba de “Tilt” Conferencia

Proceedings XXX Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB), 2012, ISBN: 10:84-616-2147-6; 13:978-84-616-2147-7.

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Bolea, J; Almeida, R; Pueyo, E; Laguna, P; Caiani, E

Ventricular Repolarization Adaptation to Abrupt Changes in Heart Rate after Microgravity Simulation by 5‐days Head‐Down Bed Rest Conferencia

Life in Space for Life on Earth, 12th European life Science symposium, Aberdeen, 2012.

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2011

Alcaine, A; Bailón, R; Romero, D; Pueyo, E; Laguna, P

Very-Low-Frequency Modulation of QRS slopes in Patients with Angina Pectoris. Conferencia

XXXVIII International Conference on Computing in Cardiology, Hangzhou, China, 2011.

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Sánchez, C; Rodriguez, B; Pueyo, E

Ionic Modulators of Electrophysiology and Re-entry Properties in Human Atria Conferencia

XXXVIII International Conference on Computing in Cardiology, Hangzhou, China, 2011.

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Bolea, J; Pueyo, E; Almeida, R; Sotaquira, M; Llamedo, M; Martínez, J P; Laguna, P; Caiani, E G

Microgravedad simulada mediante Head-Down-Bed-Resting y su influencia en la dinámica del QT/RR Conferencia

Proceedings XXIX Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB), 2011.

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Romero, D; Ringborn, M; Pueyo, E; Palhm, O; Wagner, G S; Laguna, P; Platanov, P

Análisis de la despolarización en isquemia de miocardio mediante la evaluación de las pendientes del QRS Conferencia

Proceedings XXIX Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB), 2011.

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Artículos de revista

2014

Ramírez, J; Laguna, P; de Luna, Bayés A; Malik, M; Pueyo, E

QT/RR and T-peak-to-end/RR curvatures and slopes in chronic heart failure: Relation to sudden cardiac death Artículo de revista

Journal of Electrocardiology, 47 , pp. 842– 848, 2014.

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Lázaro, J; Alcaine, A; Romero, D; Gil, E; Laguna, P; Pueyo, E; Bailón, R

Electrocardiogram Derived Respiratory Rate from QRS Slopes and R-wave Angle Artículo de revista

Annals Biomedical Enginnering, 40 (10), pp. 2072–2083, 2014.

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Sánchez, C; Bueno-Orovio, A; Wettwer, E; Loose, S; Ravens, U; Pueyo, E; Rodríguez, B

Inter-subject variability in human atrial action potential in sinus rhythm versus chronic atrial fibrillation Artículo de revista

PLOS ONE, 9 (8), pp. e105897, 2014.

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Mincholé, A; Zacur, E; Pueyo, E; Laguna, P

Modeling and Quantification of Repolarization Feature Dependency on Heart Rate Artículo de revista

Selected paper for the Special 2013 issue of methods of information in medicine, 53 (4), pp. 324-328, 2014.

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Meijs, L P B; Galeotti, L; Pueyo, E; Romero, D; Jennings, R B; Ringborn, M; Warren, S G; Wagner, G S; Strauss, D G

An Electrocardiographic Sign of Ischemic Preconditioning Artículo de revista

Am J Physiol Heart Circ Physiol, 307 , pp. H80-H87, 2014.

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Bueno-Orovio, A; Sánchez, C; Pueyo, E; Rodriguez, B

Na/K pump regulation of cardiac repolarization: insights from a systems biology approach Artículo de revista

Eur J Physiol. INVITED REVIEW., 466 , pp. 183–193, 2014.

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2013

Pueyo, E; Bailón, R; Gil, E; Martínez, J P; Laguna, P

Signal processing guided by physiology: making the most of cardio-respiratory signals Artículo de revista

IEEE Signal Processing Magazine, 30 (5), pp. 136-142, 2013.

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Pueyo, E

Coronary artery disease diagnosis by analysis of ECG depolarization Artículo de revista

Journal of Electrocardiology, 46 , pp. 27–28, 2013.

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Romero, D; Laguna, P; Pueyo, E

Detecting acute myocardial ischemai by evaluation of QRS angles Artículo de revista

International Journal of Bioelectromagnetism, 15 (1), pp. 77-82, 2013.

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Romero, D; Ringborn, M; Laguna, P; Pueyo, E

Detection and quantification of acute myocardial ischemia by morphologic evaluation of QRS changes by an angle-based method Artículo de revista

Journal of Electrocardiology, 46 , pp. 204-214, 2013.

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2012

Sánchez, C; Corrias, A; Bueno-Orovio, A; Davies, M; Swinton, J; Jacobson, I; Laguna, P; Pueyo, E; Rodriguez, B

The Na+/K+ pump is an important modulator of refractoriness and rotor dynamics in human atrial tissue Artículo de revista

Am J Physiol Heart Circ Physiol, 302 , pp. H1146-H1159, 2012.

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Romero, D; Ringborn, M; Demidova, M; Laguna, P; Koul, S; Platonov, P; Pueyo, E

Characterization of Ventricular Depolarization Changes in a Porcine Model of Myocardial Infarction Artículo de revista

Physiological Measurement, 33 , pp. 1975-1991, 2012.

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2011

Romero, D; Ringborn, M; Laguna, P; Palhm, O; Pueyo, E

Depolarization changes during acute myocardial ischemia by evaluation of QRS slopes. Standard lead and vectorial approach Artículo de revista

IEEE Transactions Biomedical Engineering, 58 , pp. 110-120, 2011.

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Mincholé, A; Pueyo, E; Rodríguez, J F; Zacur, E; Doblaré, M; Laguna, P

Quantification of Restitution Dispersion from the Dynamic Changes of the T wave peak to end, measured at the Surface ECG Artículo de revista

IEEE Transactions Biomedical Engineering, 58 (5), pp. 1172-1182, 2011.

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Ringborn, M; Romero, D; Pueyo, E; Pahlm, O; Wagner, G S; Laguna, P; Platonov, P G

Evaluation of depolarization changes during acute myocardial ischemia by analysis of QRS slopes Artículo de revista

Journal of Electrocardiology, 44 , pp. 416-424, 2011.

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Carro, J; Rodriguez, J F; Laguna, P; Pueyo, E

A human ventricular cell model for investigation of cardiac arrhythmias under hyperkalemic conditions Artículo de revista

Phil Trans Royal Soc A, 369 , pp. 4205-4232, 2011.

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Pueyo, E; Corrias, A; Virág, L; Jost, N; Szel, T; Varró, A; Szentandrássy, N; Nánási, P; Burrage, K; Rodriguez, B

A multi-scale investigation of repolarization variability and its role in cardiac arrhythmogenesis Artículo de revista

Biophys J, 101 (12), pp. 2892-2902, 2011.

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