Modelling

MODELING OF CARDIAC ELECTROPHYSIOLOGY

Imagen L1 E. Pueyo

– Research line and investigator in charge

Modeling and simulation of cardiac electrical activity in healthy and diseased hearts, including:

  1. Investigation of atrial arrhythmias: atrial activation and manifestations on electrogram (EGM) and electrocardiogram (ECG) signals
  2. Investigation of ventricular arrhythmias: mechanisms underlying the onset of reentrant arrhythmias and assessment of pro-arrhythmic risk based on ECG biomarkers
  3. Dynamic modeling of myocardial ischemia
  4. Stochastic modeling of ionic current fluctuations in ventricular cells: contribution to temporal and spatial repolarization variability.

Investigator in charge: Esther Pueyo

– Projects

  • Project 1

Title: Electrocardiographic indices for myocardial ischemia diagnosis. Correlation between cellular mechanisms and manifestations on the surface electrical signal.

Funding agency: CONSI+D DGA Ref. PI144/2009.

Dates: Oct 2009 – Oct 2011.

Principal Investigator: Esther Pueyo.

Description: This project focuses on the study of acute regional ischemia produced by coronary occlusion. A multi-scale investigation of dynamic ischemic evolution is carried out, which enables characterization of ischemic effects at the level of ion channels, cell, tissue and surface electrocardiogram. Ischemia-induced changes are linked to potential risk of suffering from arrhythmic events leading to sudden cardiac death.

  • Project 2

Title: Integrative investigation of disease and drug-induced changes in the ECG.

Funding agency: Royal Society, Joint Project, Ref. 2008/R4.

Dates: Jun 2009 – Dec 2011.

Principal Investigator: Esther Pueyo / Blanca Rodríguez.

Description: In this project new modeling and simulation techniques are developed to better characterize ventricular electrical activity. Those techniques are combined with signal processing algorithms with the aim of providing robust bio-markers to assess arryhtmic risk in two scenarios: a) in patients with coronary artery disease; b) under conditions in which drug treatment leads to cardio-toxicity.

  •  Project 3

Title: Computational investigation of cardiac arrhythmias and drug-induced effects: from ion channels to the electrocardiogram.

Funding agency: CICYT Ref. TEC2010-19410.

Dates: Jan 2011 – Dec 2013.

Principal Investigator: Esther Pueyo.

Description: This project aims at investigating mechanisms underlying the onset of cardiac arrhythmias of both atrial and ventricular origin. The effects of therapeutic approaches to prevent or terminate those arrhythmias are assessed. Computational modeling and simulation of cardiac electrophysiology and ECG signal processing are used to simulate and analyze electrical activity of atria and ventricles from subcellular levels up to the electrocardiogram.

– Technologies and targeting sectors

  •  Technology 1

Computational modeling and simulation tools to predict cardio-toxicity of drug compounds. Targeting sector: Pharmaceutical companies

  •  Technology 2

Markers for guiding the development of new agents to treat atrial fibrillation. Targeting sector: Pharmaceutical companies

– Patents and technology transfer

  •  Case 1

Technology transfer agreement with Pfizer pharmaceutical company to improve currently used methods for identification of cardio-toxic drug compounds during the development process.

  •  Case 2

Technology transfer agreement with AstraZeneca pharmaceutical company to help in the design and screening of new multi-channel action anti-atrial fibrillation drugs.

– Singular equipment

 Not available.

 – Graphic material for the website

3D atrial image from the paper ‘Ionic modulation of atrial fibrillation dynamics in a human 3D atrial model’ by C. Sánchez, M. Krueger, G. Seeman, O. Dössel, B. Rodríguez, E. Pueyo, presented at the Computing in Cardiology conference, 2012.

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