Esther Pueyo Paulés

esther-pueyo2

ESTHER PUEYO PAULES

Esther Pueyo received the M.S. degree in Mathematics from the University of Zaragoza, Spain, in 1999. During 2000, she was a research student at the Department of Mathematics, University of Zaragoza, where she developed a minor thesis in the field of Calculus, supervised by Prof. José Garay. In 2001 she started her Ph.D. studies in Biomedical Engineering at the University of Zaragoza under the supervision of Prof. Pablo Laguna, with a grant supported by the Spanish government. Her Ph.D. studies aimed at developing signal processing techniques applied to the electrocardiogram with the purpose of investigating conditions predisposing to suffer cardiac arrhythmias. During that time, she also worked as an Assistant Professor of Signal Processing at the Department of Electronic Engineering and Communications and she was a visiting scholar at research centers in Portugal, Argentina and UK, with long research visits at St. George’s Hospital Medical School, London, UK, where she worked under the supervision of Prof. Marek Malik.

After finishing her PhD in December 2006, she moved to the University of Oxford, UK (2007-2009) to get postdoctoral training in computational modeling and simulation of cardiac electrophysiology. She worked with Dr. Blanca Rodríguez and Prof. Kevin Burrage in the construction of cell and tissue models to investigate cardiac pathologies and drug-induced effects associated with increased arrhythmic risk. Most of the studies conducted during her postdoctoral period involved collaborations with experts in cardiology and experimental physiology, mainly from Hungary, UK and Sweden.

In January 2011 she was appointed Associate Professor at the University of Zaragoza, Spain. During 2012-2015 she worked as Senior Researcher at the Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) after having been awarded with a ‘Ramón y Cajal’ Senior Research fellowship by the Spanish government. At the University of Zaragoza and CIBER-BBN, she works with a group of postdoctoral researchers and PhD, MSc and undergraduate students in the development of methodologies for the analysis of simulated, experimental and clinical data. By combining ECG signal processing and electrophysiological modeling and simulation tools, her current research aims at shedding light on the mechanisms and manifestations of cardiac arrhythmias at scales ranging from cellular ion channels to the electrocardiogram and on the role of important modulators such as the Autonomic Nervous System.

Since October 2015 she is back to her Associate Professor position at the University of Zaragoza. She has participated as Principal Investigator and as Collaborator in different international, European, national and regional research projects. She is currently PI of the ERC Starting Grant project MODELAGE, funded with 1.5 M€, in which a systems biology approach is used to investigate the aging of the human heart.


CONTACT:

         Address: C/Mariano Esquillor s/n, 50018, Zaragoza (Spain)

         Phone: +34 976 762963

         E-Mail: epueyo@unizar.es

         WEB: http://www.estherpueyo.com

Artículos de revista

2018

Carro, J; Pueyo, E; Rodríguez, J F

A response surface optimization approach to adjust ionic current conductances of cardiac electrophysiological models. Application to the study of potassium level changes Artículo de revista

PLOS ONE, pp. 1-23, 2018.

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Grandi, E; Morotti, S; Pueyo, E; Rodriguez, B

Editorial: Safety Pharmacology – Risk Assessment QT Interval Prolongation and Beyond Artículo de revista

Frontieres in Physiology, 9 (678), pp. 1-5, 2018.

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Bolea, J; Bailón, R; Pueyo, E

On the standardization of approximate entropy: Multidimensional approximate entropy index evaluated on short- term HRV time series Artículo de revista

Complexity, Article ID 4953273 , pp. 1-15, 2018.

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Olivan-Viguera, A; Garcia-Otin, A L; Lozano-Gerona, J; Abarca-Lachen, E; Garcia-Malinis, A J; Hamilton, K L; Gilaberte, Y; Pueyo, E; Kohler, R

Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes Artículo de revista

PLOS ONE, 13 (1 e0190307), pp. 1-19, 2018.

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Orini, M; Pueyo, E; Laguna, P; Bailón, R

A Time-Varying Non-Parametric Methodology for Assessing Changes in QT Variability Unrelated to Heart Rate Variability Artículo de revista

IEEE Transactions Biomedical Engineering, 65 (7), pp. 1443- 1451, 2018.

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2017

Sánchez, C; Bueno-Orovio, A; Pueyo, E; Rodríguez, B

Atrial Fibrillation Dynamics and Ionic Block Effects in Six Heterogeneous Human 3D Virtual Atria with Distinct Repolarization Dynamics Artículo de revista

Front Bioeng Biotechnol., 8 , pp. 5-29, 2017.

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Ramírez, J; Orini, M; Mincholé, A; Monasterio, V; Cygankiewicz, I; de Luna, Bayés A; Martínez, J P; Laguna, P; Pueyo, E

Sudden cardiac death and pump failure death prediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model Artículo de revista

PLOS ONE, 12 (10: e0186152), pp. 1-15, 2017.

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Bolea, J; Lázaro, J; Gil, E; Rovira, E; Remartínez, J M; Laguna, P; Pueyo, E; Navarro, A; Bailón, R

Pulse rate and transit time analysis to predict hypotension events after spinal anesthesia during programmed cesarean labor Artículo de revista

Annals Biomedical Enginnering, 45 (9), pp. 2253–2263, 2017.

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Ramírez, J; Orini, M; Mincholé, A; Monasterio, V; Cygankiewicz, I; de Luna, Bayés A; Martínez, J P; Pueyo, E; Laguna, P

T-wave Morphology Restitution Predicts Sudden Cardiac Death in Patients with Chronic Heart Failure Artículo de revista

Journal of the American Heart Association, (6: e005310), pp. 1-12, 2017.

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Carro, J; Rodríguez-Matas, J F; Monasterio, V; Pueyo, E

Limitations in electrophysiological model development and validation caused by differences between simulations and experimental protocols Artículo de revista

Progress in Biophysics and Molecular Biology, 129 , pp. 53-64, 2017.

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Ramírez, J; Orini, M; Tucker, J D; Pueyo, E; Laguna, P

Variability of ventricular repolarization dispersion quantified by time-warping the morphology of the T-waves Artículo de revista

IEEE Transactions Biomedical Engineering, 64 (7), pp. 1619-1630, 2017.

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2016

Bolea, J; Pueyo, E; Orini, M; Bailón, R

Influence of heart rate in nonlinear HRV indices as a sampling rate effect evaluated on supine and standing Artículo de revista

Front. Physiol, 7 (501), pp. 1-12, 2016.

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Vicente, J; Johannesen, L; Hosseini, M; Mason, J W; Sager, P T; Pueyo, E; Strauss, D G

Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block Artículo de revista

PLOS ONE, pp. 1-16, 2016.

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Pueyo, E; Dangerfield, C E; Britton, O J; Virág, L; Kistamás, K; Szentandrássy, N; Jost, N; Varró, A; Nánási, P P; Burrage, K; Rodríguez, B

Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition Artículo de revista

PLOS ONE, pp. 1-20, 2016.

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Pueyo, E; Orini, M; Rodríguez, J F; Taggart, P

Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans Artículo de revista

Journal of Molecular and Cellular Cardiology, 97 , pp. 93-105, 2016.

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Romero, D; Martínez, J P; Laguna, P; Pueyo, E

Ischemia detection from morphological QRS angles changes Artículo de revista

Physiological Measurement, 37 , pp. 1004-1023, 2016.

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Laguna, P; Martínez, J P; Pueyo, E

Techniques for ventricular repolarization instability assessment from the ECG Artículo de revista

Proceedings of the IEEE, 104 (2), pp. 392-415, 2016.

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2015

Vicente, J; Johannesen, L; Mason, J W; Pueyo, E; Stockbridge, N; Strauss, D G

Sex Differences in Drug-Induced Changes in Ventricular Repolarization Artículo de revista

Journal of Electrocardiology, 48 , pp. 1081-1087, 2015.

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Mincholé, A; Bueno-Orovio, A; Laguna, P; Pueyo, E; Rodriguez, B

ECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk Artículo de revista

Journal of Electrocardiology, 48 , pp. 867-873, 2015.

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Vicente, J; Johannesen, L; Mason, J W; Crumb, W J; Pueyo, E; Stockbridge, N; Strauss, D G

Comprehensive T wave Morphology Assessment in a Randomized Clinical Study of Dofetilide, Quinidine, Ranolazine, and Verapamil Artículo de revista

J Am Heart Assoc, 4 (e001615), pp. 1-13, 2015.

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Ramírez, J; Monasterio, V; Mincholé, A; Llamedo, M; Lenis, G; Cygankiewicz, I; de Luna, Bayés A; Malik, M; Martínez, J P; Laguna, P; Pueyo, E

Automatic SVM classification of Sudden Cardiac Death and Pump Failure Death from Autonomic and Repolarization ECG Markers Artículo de revista

Journal of Electrocardiology, 48 , pp. 551-557, 2015.

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Conferencias

2018

García-Mendívil, L; Ramos-Marqués, E; Oliveros, J C; Torres-Pérez, R; Fernández-Bes, J; Oliván, A; Pueyo, E; Ordovás, L

Transcriptional analysis of human cardiac aging by chronological and biological age Conferencia

Aging and Metabolism, Cell Symposia, 2018.

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Ramos-Marqués, E; García-Mendívil, L; Oliveros, J C; Torres-Pérez, R; Oliván, A; Ordovás, L; Pueyo, E

Analysis of the role of microRNA in age-related heart electrophysiological remodeling Conferencia

Aging and Metabolism, Cell Symposia, 2018.

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Ramírez, J; van Duijvenboden, S; Laguna, P; Pueyo, E; Tinker, A; Lambiase, P; Munroe, P; Orini, M

Assessing a Warping Methodology for the Identification of Increased Cardiovascular Risk Based on the HR Profile Morphology Conferencia

Proceedings of the XLV International Conference on Computing in Cardiology, 2018.

BibTeX

Palacios, S; Caiani, E; Martínez, J P; Pueyo, E

Microgravity Exposure Alters Sympathetic Modulation of Ventricular Repolarization Quantified from the ECG via Periodic Repolarization Dynamics Conferencia

Proceedings of the XLV International Conference on Computing in Cardiology, 2018.

BibTeX

Bolea, J; Valenza, G; Bailón, R; Pueyo, E; Barbieri, R

Inhomogeneous Heart Rate Variability Spectral Complexity: A Preliminary Evaluation With Gravitational Stimuli Under Selective Autonomic Blockade Conferencia

Proceedings of the XLV International Conference on Computing in Cardiology, 2018.

BibTeX

Monasterio, V; Pueyo, E; Rodríguez-Matas, J F; Carro, J

Influencia de la corriente de estimulación en las diferencias entre simulaciones electrofisiológicas de célula y tejido Conferencia

XXXVI Congreso Anual de la Sociedad Española de Ingenieríıa Biomédica, Ciudad Real, España, 2018.

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2017

Ramírez, J; Orini, M; Pueyo, E; Laguna, P

Quantification of T-wave Morphological Variability Using Time-warping Methods Conferencia

Proceedings of the EMBEC 2017, NBC 2017, 2017.

Enlaces | BibTeX

Carro, J; Rodríguez-Matas, J F; Pueyo, E

Multiscale Methods for Definition of Ionic Variables in Electrophysiological Models Conferencia

Proceedings of the EMBEC 2017, NBC 2017, 2017.

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Sampedro-Puente, D A; Fernandez-Bes, J; Pueyo, E

Differential Responses to Beta-Adrenergic Stimulation in the Long-QT Syndrome Type 1: Characterization and Mechanisms Conferencia

Proceedings of the XLIV International Conference on Computing in Cardiology, Rennes, France, 2017.

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Fernandez-Bes, J; Sampedro-Puente, D A; Pueyo, E

Identification of Parameters describing Phenomenological Cardiac Action Potential Models using Sigma-Point Methods Conferencia

Proceedings of the XLIV International Conference on Computing in Cardiology, Rennes, France, 2017.

Enlaces | BibTeX

Ramírez, J; Orini, M; Pueyo, E; Laguna, P

Comparison of ECG T-wave Duration and Morphology Restitution Markers for Sudden Cardiac Death Prediction in Chronic Heart Failure Conferencia

Proceedings of the XLIV International Conference on Computing in Cardiology, Rennes, France, 2017.

Enlaces | BibTeX

Ramírez, J; Orini, M; Pueyo, E; Laguna, P

T-wave Morphology Restitution Dependency with Heart Rate Range and Its Association with Sudden Cardiac Death in Chronic Heart Failure Conferencia

Proceedings of the XLIV International Conference on Computing in Cardiology, Rennes, France, 2017.

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2016

Ramírez, J; Orini, M; Tucker, J D; Pueyo, E; Laguna, P

An Index for T-wave Pointwise Amplitude Variability Quantification Conferencia

Proceedings of the XLIII International Conference on Computing in Cardiology, Vancouver, BC, Canada, 2016.

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Ramírez, J; Orini, M; Tucker, J D; Pueyo, E; Laguna, P

Cuantificación de la Variabilidad de la Amplitud de la Onda T Mediante Técnicas de Re-parametrización Temporal Conferencia

Proceedings XXXIV Congreso Anual de la Sociedad Española de Ingeniería Biomédica, 2016, ISBN: 978-84-9048-531-6.

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2015

Monasterio, V; Carro, J; Pueyo, E; Rodríguez, J F

The Role of Purkinje Automaticity as an Arrhythmia Mechanism in Hyperkalaemia Conferencia

XLII International Conference on Computing in Cardiology, Nice, France, 2015.

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Vicente, J; Johannesen, L; Mason, J W; Crumb, W J; Pueyo, E; Stockbridge, N; Strauss, D G

Comprehensive Analysis of Novel Electrocardiographic Device Algorithms for Differentiating Arrhythmic Risk Conferencia

FDA Science Forum, Silver Spring, MD, 2015.

BibTeX

Vicente, J; Johannesen, L; Mason, J W; Pueyo, E; Stockbridge, N; Strauss, D G

Sex Differences in Drug-Induced Changes in Ventricular Repolarization Conferencia

International Society of Computerized Electrocardiology, San Jose, California, US, 2015.

BibTeX

Caiani, E G; Martín-Yebra, A; Pellegrini, A; Bolea, J; Auricchio, A; Pueyo, E; Vaida, P

High protein intake supplementation to compensate changes in ventricular repolarization due to 21-days of bedridden immobilization Conferencia

ESC; European Heart Journal, 2015.

BibTeX

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